{"title":"细胞内因子XIII:人体内因子XIII亚基a的细胞分布","authors":"R. Ádány","doi":"10.1055/s-2007-999038","DOIUrl":null,"url":null,"abstract":"In addition to the plasma where factor XIII subunit A is present as part of the heterodimers of the tetrameric fibrin-stabilizing factor, homodimers of factor XIII A can also be detected in cellular localization in different human tissues. Experimental findings verified that these cells belong to the megakaryocyte/ platelet and the monocyte/macrophage cell lines. Additionally, factor XIII A is present in hepatocytes localized mainly around central veins in the liver and occasionally expressed in certain malignantly transformed cells. It is reasonable to suppose that factor XIII A acts not only as a member of the clotting cascade, but also as a cellular enzyme that can catalyze molecular interactions intracellularly (during the assembly/reassembly of the cytoskeleton) or extracellularly (in the connective tissue matrix around the cells containing it).","PeriodicalId":134471,"journal":{"name":"Seminars in Thrombosis and Hemostatis","volume":"40 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1996-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"34","resultStr":"{\"title\":\"Intracellular Factor XIII: Cellular Distribution of Factor XIII Subunit a in Humans\",\"authors\":\"R. Ádány\",\"doi\":\"10.1055/s-2007-999038\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In addition to the plasma where factor XIII subunit A is present as part of the heterodimers of the tetrameric fibrin-stabilizing factor, homodimers of factor XIII A can also be detected in cellular localization in different human tissues. Experimental findings verified that these cells belong to the megakaryocyte/ platelet and the monocyte/macrophage cell lines. Additionally, factor XIII A is present in hepatocytes localized mainly around central veins in the liver and occasionally expressed in certain malignantly transformed cells. It is reasonable to suppose that factor XIII A acts not only as a member of the clotting cascade, but also as a cellular enzyme that can catalyze molecular interactions intracellularly (during the assembly/reassembly of the cytoskeleton) or extracellularly (in the connective tissue matrix around the cells containing it).\",\"PeriodicalId\":134471,\"journal\":{\"name\":\"Seminars in Thrombosis and Hemostatis\",\"volume\":\"40 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"34\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in Thrombosis and Hemostatis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/s-2007-999038\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Thrombosis and Hemostatis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-2007-999038","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Intracellular Factor XIII: Cellular Distribution of Factor XIII Subunit a in Humans
In addition to the plasma where factor XIII subunit A is present as part of the heterodimers of the tetrameric fibrin-stabilizing factor, homodimers of factor XIII A can also be detected in cellular localization in different human tissues. Experimental findings verified that these cells belong to the megakaryocyte/ platelet and the monocyte/macrophage cell lines. Additionally, factor XIII A is present in hepatocytes localized mainly around central veins in the liver and occasionally expressed in certain malignantly transformed cells. It is reasonable to suppose that factor XIII A acts not only as a member of the clotting cascade, but also as a cellular enzyme that can catalyze molecular interactions intracellularly (during the assembly/reassembly of the cytoskeleton) or extracellularly (in the connective tissue matrix around the cells containing it).
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