体外单细胞光遗传学研究突触印迹的平台

Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN) Pub Date : 1900-01-01 DOI:10.1364/boda.2023.dtu2a.5

Clara Zaccaria, Asiye Malkoç, Beatrice Vignoli, M. Canossa, L. Pavesi

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引用次数: 0

摘要

记忆依赖于同时激活的神经元(印迹)的放电，其突触通过长期增强机制得到加强。将光遗传学工具和荧光探针与数字光处理器设备(DLP)相结合，创建体外印迹并研究增强棘种群。

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A Platform for Single Cell Optogenetics to Study Synaptic Engrams in Vitro

Memory relies on the firing of simultaneously activated neurons (engram), whose synapses are strengthened by long-term potentiation mechanisms. Optogenetic tools and a fluorescence probe to map synaptic engrams, were combined with a digital light processor device (DLP), to create in-vitro engrams and study populations of potentiated spines.

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来源期刊

Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)

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