{"title":"某些嘌呤霉素类似物的合成及其在大肠杆菌和大鼠肝核糖体肽基合成酶研究中的应用。","authors":"M Ariatti, A O Hawtrey","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The beta-alanyl and L-histidyl analogues of puromycin were synthesized chemically and tested for their ability to release [3H] N-acetylphenylalanine from its tRNA carrier in the rat liver and E. Coli ribosomal systems. Both analogues were found to be inactive in releasing [3H] N-acetylphenylalanine. Reasons for the inactivity of these compounds are discussed in relation to the structure of the puromycin molecule and the requirements for puromycin-like activity.</p>","PeriodicalId":22995,"journal":{"name":"The South African journal of medical sciences","volume":"40 4","pages":"197-203"},"PeriodicalIF":0.0000,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of certain puromycin analogues and their use in studying the peptidyl synthetase enzyme of e. coli and rat liver ribosomes.\",\"authors\":\"M Ariatti, A O Hawtrey\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The beta-alanyl and L-histidyl analogues of puromycin were synthesized chemically and tested for their ability to release [3H] N-acetylphenylalanine from its tRNA carrier in the rat liver and E. Coli ribosomal systems. Both analogues were found to be inactive in releasing [3H] N-acetylphenylalanine. Reasons for the inactivity of these compounds are discussed in relation to the structure of the puromycin molecule and the requirements for puromycin-like activity.</p>\",\"PeriodicalId\":22995,\"journal\":{\"name\":\"The South African journal of medical sciences\",\"volume\":\"40 4\",\"pages\":\"197-203\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The South African journal of medical sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The South African journal of medical sciences","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
用化学方法合成了嘌呤霉素的β -丙酰和l -组氨酸类似物，并测试了它们在大鼠肝脏和大肠杆菌核糖体系统中从tRNA载体释放[3H] n -乙酰苯丙氨酸的能力。发现这两种类似物在释放[3H] n -乙酰苯丙氨酸方面无活性。这些化合物缺乏活性的原因与嘌呤霉素分子的结构和嘌呤霉素样活性的要求有关。
Synthesis of certain puromycin analogues and their use in studying the peptidyl synthetase enzyme of e. coli and rat liver ribosomes.
The beta-alanyl and L-histidyl analogues of puromycin were synthesized chemically and tested for their ability to release [3H] N-acetylphenylalanine from its tRNA carrier in the rat liver and E. Coli ribosomal systems. Both analogues were found to be inactive in releasing [3H] N-acetylphenylalanine. Reasons for the inactivity of these compounds are discussed in relation to the structure of the puromycin molecule and the requirements for puromycin-like activity.
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