Correction of the functional state of the regulatory systems of the body of dogs under the influence of environmental stress factors

The study was conducted on 15 dogs aged 1.5-12 years, kept in urban conditions with symptoms of chronic stress caused by various factors: moving to a new place of residence, fear of loneliness, loss of the owner, exhibition career, active breeding activities. The drug Klim Peter was given to all animals for 21 days at a dosage of 1 tablet per 10 kg of live weight 1 time per day. Blood samples were taken for morphological and biochemical studies before the start of the study and after the use of the drug (on the 24th day from the start of the experiment). The drug contributed to a significant reduction in the initially elevated level of white blood cells, the number of red blood cells and the concentration of hemoglobin, a decrease in ESR. The ratio of white blood cells in the leukogram approached the standard values. Protein and albumin levels were significantly increased.The normalization of anabolic processes was confirmed by a decrease in urea and creatinine levels, as well as a significant decrease in the level of bilirubin and the activity of enzymes – ALT, AST and alkaline phosphatase. After 5-10 days after the start of taking the drug, the animals showed normalization of appetite and digestion, after 14-18 days, neurological symptoms were leveled (destructive behavior, tremor, unmotivated aggression, obsessive behavior). By the 20th day, there was an improvement in the condition of the skin and coat, molting in most stopped or decreased, the coat became thick, shiny. Thus, the use of the drug Klim Pet had a positive effect on the clinical condition, and also helped to neutralize the effects of stress factors of various etiologies, had a hepatoprotective effect, optimized the metabolism and activity of the immune and nervous systems, contributed to improving the condition of the fur and skin.