拓扑异构酶II summoylation通过Haspin和Aurora B激酶激活中期检查点

The Journal of Cell Biology Pub Date : 2019-11-11 DOI:10.1083/jcb.201807189

Nootan Pandey, Daniel Keifenheim, M. Yoshida, Victoria A Hassebroek, Caitlin Soroka, Y. Azuma, D. J. Clarke

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引用次数: 18

摘要

为了防止染色体错分离，当拓扑异构酶II被催化抑制和DNA连环化持续存在时，中期检查点被激活。Pandey等剖析了触发这一调控系统的关键分子事件。

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Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases

To prevent chromosome missegregation, a metaphase checkpoint is activated when topoisomerase II is catalytically inhibited and DNA catenations persist. Pandey et al. dissect the key molecular events triggering this regulatory system.

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The Journal of Cell Biology

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