可持续抗生素膜自组装胶体系统

D. Moran, Clara Saweres-Argüelles, Verdiana Marchianò, Shayesteh Bazsefidpar, E. Serrano-Pertierra, M. Matos, G. Gutiérrez, M. Blanco-López
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引用次数: 0

摘要

生物膜在食品、化妆品或医疗假体和设备等工业过程中找到了有利的环境,大约80%的人类细菌感染是由生物膜引起的。预防和/或根除微生物膜是全世界的需要。人们对发现和使用无副作用的新型抗菌化合物越来越感兴趣。另一个挑战是对抗一些细菌和微生物对传统抗生素产生的抗微生物药物耐药性。此外,近年来,可持续性和天然来源的抗生素膜化学原理也是一个优先的要求。胶体系统,如囊泡、颗粒悬浮液或乳液,由于它们能够保护被封装的化合物免受外部因素的影响,并且它们可能被用作目标递送系统,因此正成为生物化合物递送的越来越有用的工具。在过去的十年中,这些类型的系统已被广泛用于包封具有抗菌特性的传统和新型化合物。本研究综述了不同类型的天然化合物对几种类型的细菌的测试及其在不同类型的胶体系统中被封装的可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sustainable antibiofilm self-assembled colloidal systems
Biofilms find a favorable environment in industrial processes such as food, cosmetic, or medical prosthesis and devices, being responsible of approximately 80% of human bacterial infections. Prevention and/or eradication of microorganism’ films is a worldwide need. There is an increasing interest on the finding and use of novel antimicrobial compounds without side effects. An additional challenge is to fight the antimicrobial resistance that some bacteria and microorganisms develop with traditional antibiotics. Also, in recent years, sustainability and natural source of the antibiofilm chemical principles are also a priority demand. Colloidal systems such as vesicles, particle suspensions, or emulsions are becoming increasingly useful tools for biocompound delivery due to their ability to protect the compound encapsulated against external factors and their possibility to be used as target delivery systems. During the last decade, these types of systems have been widely used for the encapsulation of traditional and novel compounds with antimicrobial properties. The present study summarizes different types of natural compounds tested against several types of bacteria and their feasibility to be encapsulated in different types of colloidal systems.
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