B. Vivek, Ashish Kumar Jain, J. Sawhney, R. Jain, R. Passey, A. Mohanty
{"title":"漏诊的心脏淀粉样变性:一种潜在可治疗的疾病","authors":"B. Vivek, Ashish Kumar Jain, J. Sawhney, R. Jain, R. Passey, A. Mohanty","doi":"10.1177/26324636231186910","DOIUrl":null,"url":null,"abstract":"Aim To highlight the prevailing lack of suspicion of cardiac amyloidosis (CA) amongst physicians, leading to preventable delay in management of patients of heart failure (HF). Methods Six patients of CA diagnosed in 6 months were retrospectively analyzed. Clinical history, investigations, treatment, and follow-up data is analyzed. Result A speckled interventricular septum on echo favored CA. Speckle tracking showed reduced global longitudinal strain with typical left ventricular apical sparing in all patients. Bone marrow study confirmed light chain amyloidosis (AL) in all patients. Conclusion CA, a frequently missed diagnosis, can be detected early with the help of clinical red flag signs, echocardiogram, serum and urine immune electrophoresis and bone scan.","PeriodicalId":429933,"journal":{"name":"Indian Journal of Clinical Cardiology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Missed Cardiac Amyloidosis: A Potentially Treatable Disease\",\"authors\":\"B. Vivek, Ashish Kumar Jain, J. Sawhney, R. Jain, R. Passey, A. Mohanty\",\"doi\":\"10.1177/26324636231186910\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim To highlight the prevailing lack of suspicion of cardiac amyloidosis (CA) amongst physicians, leading to preventable delay in management of patients of heart failure (HF). Methods Six patients of CA diagnosed in 6 months were retrospectively analyzed. Clinical history, investigations, treatment, and follow-up data is analyzed. Result A speckled interventricular septum on echo favored CA. Speckle tracking showed reduced global longitudinal strain with typical left ventricular apical sparing in all patients. Bone marrow study confirmed light chain amyloidosis (AL) in all patients. Conclusion CA, a frequently missed diagnosis, can be detected early with the help of clinical red flag signs, echocardiogram, serum and urine immune electrophoresis and bone scan.\",\"PeriodicalId\":429933,\"journal\":{\"name\":\"Indian Journal of Clinical Cardiology\",\"volume\":\"18 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Clinical Cardiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/26324636231186910\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Clinical Cardiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/26324636231186910","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Missed Cardiac Amyloidosis: A Potentially Treatable Disease
Aim To highlight the prevailing lack of suspicion of cardiac amyloidosis (CA) amongst physicians, leading to preventable delay in management of patients of heart failure (HF). Methods Six patients of CA diagnosed in 6 months were retrospectively analyzed. Clinical history, investigations, treatment, and follow-up data is analyzed. Result A speckled interventricular septum on echo favored CA. Speckle tracking showed reduced global longitudinal strain with typical left ventricular apical sparing in all patients. Bone marrow study confirmed light chain amyloidosis (AL) in all patients. Conclusion CA, a frequently missed diagnosis, can be detected early with the help of clinical red flag signs, echocardiogram, serum and urine immune electrophoresis and bone scan.
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