非肌性浸润性膀胱癌TURBT术后膀胱内灌注丝裂霉素c与持续膀胱盐水冲洗(CSBI)的疗效和安全性比较

A. Bhat, Z. Bhat
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引用次数: 0

摘要

目的比较低至中危非肌肉浸润性膀胱癌经尿道膀胱肿瘤切除术(TURBT)后持续盐水膀胱冲洗与单次应用丝裂霉素c (MMC)的疗效和安全性。材料和方法考虑的问题最好通过批判性地回顾和分析文献来回答,最后提供有关文献结论相关性的建议。在研究问题的背景下,搜索研究从知名的学术数据库中识别相关文献。以不同的格式使用特定的关键字集来搜索文献。文献已经彻底审查和分析的优势和局限性。根据文献文章的类型,特别参考文献文章的有用性、知识、态度、可转移性、有效性/可靠性和结论的强度,严格地采用具体数据进行分析。结果对符合入选标准的6篇论文进行了批判性分析,比较了膀胱内化疗与持续盐水膀胱灌洗(CSBI)的疗效和安全性。结论csbi在预防复发和进展方面不能替代MMC,但由于csbi具有更好的安全性,可作为低至中危膀胱癌患者TURBT术后的替代方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Efficacy and Safety between Post-operative Intra-vesical Instillation of Mitomycin-C and Continuous Saline Bladder Irrigation (CSBI) after TURBT in Non-muscle Invasive Bladder Cancers
ObjectiveTo critically analyse the efficacy and safety of continuous saline bladder irrigation versus single installation of mitomycin-C (MMC) after transurethral resection of bladder tumour (TURBT) in patients with low to intermediate risk non-muscle invasive bladder cancer. Materials and MethodsThe question in consideration best merits answer by critically reviewing and analyzing the literature and finally to provide the recommendation about the relevance of the conclusions from the literature. A search study identifies the relevant literature from the well-known academic databases in the context of the re-search question. The particular sets of the key words are used in different formats to search the literature. The literature has been thoroughly reviewed and analyzed for the strengths and limitations. Specific data was critically taken for analysis depending upon the type of literature articles with special reference to their usefulness, knowledge, attitudes, transferability, validity/reliability and strength of conclusions. ResultsA total of 6 papers meeting the inclusion criteria, which compared the results of the efficacy and safety between intravesical chemotherapy and continuous saline bladder irrigation (CSBI) were critically analyzed. ConclusionCSBI cannot replace MMC in terms of its efficacy in the prevention of recurrence and progression but because of the better safety profile can be used as an alternative in patients with low to intermediate risk bladder cancers after TURBT.
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