具有控释的多模态上转换纳米颗粒给药系统

2020 International Conference Laser Optics (ICLO) Pub Date : 2020-11-02 DOI:10.1109/ICLO48556.2020.9285550

P. Demina, N. Sholina, R. Akasov, N. Arkharova, Y. Grigoriev, I. Asharchuk, A. V. Nechaev, E. Khaydukov, A. Generalova

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引用次数: 0

摘要

镧系掺杂上转换纳米粒子作为光学生物成像和药物传递系统的纳米平台受到了广泛的关注。在这项工作中，我们开发了基于热敏聚合物和银纳米粒子(AgNPs)修饰的UCNPs的多模态系统，其中含有化疗药物，如阿霉素和黄素单核苷酸，用于可视化和治疗。研究了其给药性能、细胞毒性和光学性能。

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Multimodal upconversion nanoparticles with controlled drug release as drug delivery system

The lanthanide-doped upconversion nanoparticles (UCNPs) gained great attention as nanoplatforms for optical bioimaging and drug delivery systems. In this work, we developed the multimodal system based on UCNPs modified with thermosensitive polymer and Ag nanoparticles (AgNPs), containing chemotherapeutics, such as doxorubicin and flavin mononucleotide, for visualization and therapy. The drug delivery, cytotoxicity and optical properties were studied.

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2020 International Conference Laser Optics (ICLO)

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