{"title":"新型白藜芦醇衍生物的多重生物学效应","authors":"João Lucas Bruno Prates, J. D. dos Santos","doi":"10.53365/nrfhh/156437","DOIUrl":null,"url":null,"abstract":"The development of new drugs is a long-term and expensive process. Among the strategies to find out new drugs, natural products have an important role in providing new drugs and prototypes. However, physicochemical and pharmacokinetics properties demand chemical optimization for many natural products to improve their safety and efficacy. Molecular modifications (MM) represent a successful approach to optimising such properties. Here, we describe the use of MM to enhance the properties of resveratrol. Thus, we described some strategies to find new resveratrol derivatives useful as sunscreen and treat sickle cell disease. Some examples are described, showing the role of MM in discovering new bioactive compounds.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"38 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The multiple biological effects of new resveratrol derivatives\",\"authors\":\"João Lucas Bruno Prates, J. D. dos Santos\",\"doi\":\"10.53365/nrfhh/156437\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The development of new drugs is a long-term and expensive process. Among the strategies to find out new drugs, natural products have an important role in providing new drugs and prototypes. However, physicochemical and pharmacokinetics properties demand chemical optimization for many natural products to improve their safety and efficacy. Molecular modifications (MM) represent a successful approach to optimising such properties. Here, we describe the use of MM to enhance the properties of resveratrol. Thus, we described some strategies to find new resveratrol derivatives useful as sunscreen and treat sickle cell disease. Some examples are described, showing the role of MM in discovering new bioactive compounds.\",\"PeriodicalId\":394827,\"journal\":{\"name\":\"Natural Resources for Human Health\",\"volume\":\"38 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Resources for Human Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.53365/nrfhh/156437\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Resources for Human Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53365/nrfhh/156437","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The multiple biological effects of new resveratrol derivatives
The development of new drugs is a long-term and expensive process. Among the strategies to find out new drugs, natural products have an important role in providing new drugs and prototypes. However, physicochemical and pharmacokinetics properties demand chemical optimization for many natural products to improve their safety and efficacy. Molecular modifications (MM) represent a successful approach to optimising such properties. Here, we describe the use of MM to enhance the properties of resveratrol. Thus, we described some strategies to find new resveratrol derivatives useful as sunscreen and treat sickle cell disease. Some examples are described, showing the role of MM in discovering new bioactive compounds.
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