Synthesis, Biological Activity, and Molecular Docking Studied of New Substituted Hydrazones

Series of new hydrazones derived from different carboxylic acid hydrazides and aromatic aldehydes (7-10, 20-25) have been synthesized and characterized by spectral techniques (FT-IR, 1H NMR, 13C NMR, and Mass spectrometry). The target compounds are designed to have the different substituents at the para position for both parts of the structures (hydrazide and aldehyde parts. The synthesized compounds have been evaluated as antimicrobial agents by studying their biological activity against two bacteria strains Staphylococcus aureus and Staphylococcus epidermidis (as gram-positive bacteria), Escherichia coli and Klebsiella sp (as gram-negative bacteria), the antifungal activity was studied against Candida albicans fungi. The obtained results showed a moderate antimicrobial activity for the test compounds when compared with ampicillin. The synthesized compounds were also subjected to molecular docking studies which were carried out against the bacteria strain Staphylococcus aureus DHFR.