腹膜积液中癌细胞的显微图像分割与识别研究

Hongyuan Wang, Shenggen Zeng, Chengang Yu, Xiaogang Wang, Deshen Xia
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引用次数: 5

摘要

由于细胞组织的复杂性和视频显微图像的固有问题,细胞的自动分割是最有趣的分割问题之一。对象的多变性、灰度范围窄、非随机噪声是这类图像普遍存在的问题。考虑到上述特点,本文提出了一种自适应最小距离算法,可从腹膜积液细胞显微图像的复杂背景中分割出可疑的细胞和细胞核。分别给出了癌细胞的15个特征及其计算公式。利用这些特征构建反向传播神经网络分类器,对落入腹膜积液的癌细胞进行分类和识别。利用病理学家推荐的临床病例进行了测试,结果表明,该算法可以有效地分割细胞图像,获得较高的癌细胞诊断准确率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The research of microscopic image segmentation and recognition on the cancer cells fallen into peritoneal effusion
Auto-segmentation of cells is one of the most interesting segmentation problems due to the complex nature of the cell tissues and to the inherent problems of video microscopic images. Objects, which are variant, narrow range of gray levels, non-random noise, are ubiquitous problems presented in this kind of image. Considering the above characteristics, an adaptive min-distance algorithm is proposed in this paper, which is available to segment the suspected cell and nucleus from the complex background in the microscopic image of cells fallen into peritoneal effusion. 15 features of the cancer cell and calculating formulas are presented respectively. These features are employed to construct a backpropagation neural network classifier which classifies and recognizes the cancer cells fallen into peritoneal effusion. Tests are performed using clinical cases recommended by the pathologists, results show that the proposed algorithm can efficiently segment the cell image and receive higher accuracy of cancer cell diagnosis.
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