聚酰亚胺基神经界面薄膜刺激接触的体外长期稳定性研究

P. C̆vanc̆ara, Inga Bartels, T. Stieglitz
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引用次数: 0

摘要

微机械外周神经接口已成功进入转化研究。聚酰亚胺基界面基材具有化学惰性、机械柔韧性和低吸水性。它们允许神经界面的厚度为10微米,减少严重炎症反应的可能性。为了在这个范围内实现器件厚度,采用光刻工艺沉积几百纳米范围内的薄膜金属化。为了证明在化学安全刺激范围内的长期稳定性,对溅射氧化铱膜的刺激接触部位进行了体外刺激。45亿次脉冲后,第一次发生电化学变化,表现为阻抗大小减小,同时阴极电荷存储容量增加。两种情况都表明有效表面积发生了变化。使用白光干涉测量法和扫描电子显微镜结合聚焦离子束对这些接触部位进行了光学深度分析,证实了裂纹的形成和分层。然而,对于所有其他接触点,进一步刺激高达65亿脉冲。按照保守的方法,假设每次接触刺激都要进行日常工作,这一数量估计约为6.6年的慢性人体刺激。长期刺激的结果表明,长期刺激对寿命较长的人类的研究具有稳定性,可以用于更大的受试者队列的首次转译研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
On the in vitro long-term stability of thin-film stimulation contacts in polyimide-based neural interfaces
Micro-machined peripheral nerve interfaces have entered translational research successfully. Polyimide-based interface substrates showed chemical inertness, mechanical flexibility and low water uptake. They allow neural interface with a thicknesses of ten micrometer reducing the probability of severe inflammatory reactions. To realize device thicknesses in this range, photolithographic processes are used to deposit thin-film metallization in the range of a few hundred nanometers. In order to prove long-term stability within chemical safe stimulation limits, in vitro stimulation of sputtered iridium oxide film stimulation contact sites was performed. After 4.5 billion pulses, first electrochemical changes occurred indicated by a decrease in impedance magnitude and simultaneously an increase of the cathodic charge storage capacity. Both scenarios indicated a change in the effective surface area. These contact sites were used for an optical in depth analysis using white light interferometry and scanning electron microscopy in combination with a focused ion beam, which confirmed crack formation and delamination. However, for all other contact sites further stimulation up to 6.5 billion pulses was applied. This amount was estimated about 6.6 years of stimulation in chronic human application with a conservative approach assuming daily work with each stimulation contact. The outcome of the long-term stimulation indicates stability for chronic stimulation studies in humans with life-times reasonably long for first translational studies on larger subject cohorts.
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