罕见膜抗原特异性人B细胞的鉴定

N. Sanderson
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引用次数: 0

摘要

MG病理是由IgG类抗体在神经肌肉连接处与AChR结合,激活补体,并可能导致受体内化或其功能阻断引起的,这一模型得到了实验的充分支持,这使得一系列合理有效的治疗得以发展。更好地了解哪些B细胞负责产生这些致病性抗体,以及为什么这些B细胞会产生,将有助于开发更有针对性的治疗方法。从患者的单个B细胞中分离的抗体的研究提供了一些从血清中多克隆抗体的研究中无法获得的信息,但也许未来对B细胞本身的研究将提供对疾病原因的更深入的了解,从而使其能够预防。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification of Rare Membrane Antigen Specific Human B Cells
The experimentally well supported model that MG pathology is caused by antibodies of the IgG class that bind to AChR at the neuromuscular junction, activate complement, and possibly cause internalization of receptors or their functional blockade has enabled the development of a range of reasonably effective treatments. A better understanding of which B cells are responsible for producing these pathogenic antibodies, and why such B cells develop would enable the development of more targeted therapies. Studies of antibodies isolated from single B cells from patients have provided some of this information that was not available from studies of polyclonal antibodies in sera, but perhaps future studies of the B cells themselves will provide deeper insight into the causes of the disease and thereby enable its prevention.
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