红外光谱数字成像与骨癌诊断

J. Anastassopoulou, A. Mavrogenis, T. Theophanides
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引用次数: 1

摘要

今天,科学家们正在追求非破坏性和非侵入性方法的发展,以便以数字形式快速可靠地诊断疾病,减少对活组织检查的需求。本文综述了近年来支持傅里叶变换红外光谱与红外热成像或医用热成像应用的最新研究进展。这两种技术都是非破坏性的数字技术,有望记录和区分由疾病引起的局部生化变化,而检测的样品不需要任何特殊的准备。来自身体受影响区域的反射红外辐射强烈依赖于癌症/或任何其他疾病的代谢步骤,这也与疾病的酶促或非酶促步骤期间生物分子在分子水平上的结构变化有关。检测所获得的细胞、液体或组织成分变化的FT-IR光谱数字“标记带”均来源于疾病检查点。此外,对癌区热成像的ImageJ分析显示,在癌症发展过程中,聚集物的形成也从FT-IR光谱中得到了证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Infrared Spectral Digital Imaging and Bone Cancer Diagnostic
Scientists today are pursuing the development of non-destructive and non-invasive methods for rapid and reliable diagnosis of diseases in digital form and reduction in the need for biopsies. In this paper we review the most recent studies supporting the application of Fourier Transform Infrared (FT-IR) spectroscopy and infrared thermography or medical thermography. Both are non-destructive digital techniques, which are promising to record and discriminate the local biochemical changes that are induced by the diseases, while the examined samples do not need any special preparation. The reflected infrared radiation from the affected areas of the body strongly depends on the metabolic steps of the cancer/or any other disease, which is also related to the structural changes at a molecular level of the biological molecules during enzymatic or non-enzymatic steps of the disease. The detection of the FT-IR spectral digital “marker bands” of the obtained changes of cell, liquids or tissue components are derived from the disease in the check point. Furthermore, ImageJ analysis of the thermal imaging in cancerous area showed aggregate formation upon cancer development as it was also indicated from the FT-IR spectra.
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