神经退行性疾病中的蛋白质错误折叠

Hc Scott
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引用次数: 2

摘要

许多神经退行性疾病具有共同的特征和分子模式,这表明它们的病理可能具有直接可比性。帕金森病、阿尔茨海默病和朊病毒病等疾病的特征都是蛋白质异常积聚和选择性神经元变性。本文综述了这些疾病的病理和病因,探讨了它们之间的联系,包括自由基积累缺陷,线粒体功能障碍和蛋白质降解途径的损害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protein-misfolding in neurodegenerative disease
Many of the neurodegenerative diseases share common features and molecular patterns that suggest their pathology may be directly comparable. Diseases such as Parkinson’s disease, Alzheimer’s disease and Prion diseases are all characterised by abnormal accumulations of proteins and selective neuronal degeneration. This article reviews the known pathology and aetiology of these diseases in order to explore the links between them including defective free radical accumulation, mitochondrial dysfunction and impairment of protein degradation pathways.
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