胃肠病学家治疗肠易激综合征:来自专家调查的横断面研究结果

L. Soifer, J. Tawil, Alejandro Rey, L. Solé, Silvia Bernstein
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摘要

介绍。肠易激综合征(IBS)是患者生活质量显著恶化的原因,也是胃肠病学咨询的常见原因。该综合征的治疗包括基于其生理病理不同因素的各种药物和建议。然而,结果通常是可变的,有时对病人或治疗医生都不满意。目前工作的主要目的是描述胃肠病学家在阿根廷IBS管理中使用的不同治疗方法。材料和方法。47个问题的调查问卷,由专家准备,由阿根廷胃肠病学医学协会分发,并由专家通过谷歌表格回答。结果:304份回复,女性157份(51.6%),男性147份(48.4%)。平均年龄分别为44岁和49.9岁。87.5%的人认为改善生活质量是治疗的主要目标。在腹泻型肠易激综合征(IBS-D)的生理病理中,49.5%的人认为是情绪应激,而便秘型肠易激综合征(IBS-C)的生理病理中,42.8%的人认为是多因素的,以慢结肠运输为主。没有一种治疗方案被超过50%的受访者评为非常有效。利福昔明被认为是IBS-D最有效的治疗方法,而聚乙二醇是IBS-C最有效的治疗方法。胃肠病学亚专科在治疗IBS-D方面,在饮食、阿米替林和除利福昔明以外的抗生素的疗效方面,以及在治疗IBS-C方面,在比沙代碱/picosulfate和抗生素的疗效方面,观察到有统计学意义的差异。结论。IBS-D最常见的病理生理机制是压力。绝大多数受访者认为治疗的主要目标是改善生活质量,而不是缓解症状。至少有50%的受访者认为,没有一种药物对不同的肠易激综合征变体的治疗非常有效。在IBS的每月咨询比例与年龄和某些治疗方法的有效性方面观察到统计学上的显著差异,这些治疗方法与医生的专科有关。阿根廷胃肠病学家对IBS的治疗方法是多种多样的,有些异质,导致这种情况的管理仍然不适当。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tratamiento del síndrome de intestino irritable por gastroenterólogos: resultados de un estudio de corte transversal a partir de una encuesta elaborada por expertos
Introduction. Irritable bowel syndrome (IBS) accounts for a significant deterioration in the quality of life of patients who suffer from it and is a common reason for consultation in gastroenterology. The treatment of this syndrome includes a wide variety of medications and recommendations based on different factors of its physiopathology. However, the results are usually variable and sometimes unsatisfactory for either the patient or the treating physician. The main objective of the present work is to describe the different treatments used by gastroenterologists in the management of IBS in Argentina. Materials and methods. Questionnaire of forty-seven questions, prepared by experts, distributed by medical associations of gastroenterology in Argentina and answered by specialists via Google Forms. Results. 304 responses, 157 from women (51.6%) and 147 from men (48.4%). The mean age was 44 and 49.9 years, respectively. 87.5% consider improvement of quality of life as the main goal of treatment. Regarding physiopathology of diarrhea variant irritable bowel syndrome (IBS-D), 49.5% considered emotional stress, while for constipation variant irritable bowel syndrome (IBS-C), 42.8% considered it multifactorial, with a predominance of slow colonic transit. No treatment option was rated as very effective by more than 50% of the respondents. Rifaximin was considered the most effective treatment in IBS-D, while polyethylene glycol was for IBS-C. Statistical significant differences were observed among gastroenterology subspecialties in the treatment of IBS-D with respect to the efficacy of diet, amitriptyline and antibiotics other than rifaximin, and regarding the effectiveness for bisacodyl/picosulfate and antibiotics in the treatment of IBS-C. Conclusion. The most common pathophysiological mechanismin IBS-D is stress. The vast majority of respondents consider that the main goal of treatment is the improvement of the quality of life, over symptomatic relief. None of the drugs is considered very effective in the treatment of the different IBS variants by at least 50% of those surveyed. Statistically significant differences were observed in the proportion of monthly consultations for IBS regarding to age and in the effectiveness considered for some treatments in relation to the subspecialty of physicians. The therapeutic approach to IBS by Argentine gastroenterologists is varied and somewhat heterogeneous, resulting in a still inappropriate management of this condition.
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