用于荧光生物医学成像的纳米滤波器集成CMOS图像传感器

2018 IEEE Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2018-10-01 DOI:10.1109/BIOCAS.2018.8584706

Yu Jiang, Hao Yu, Xiaojian Fu, Chathuranga Hettiarachchi, He Xu, Ye Li, T. Nguyen, Longtao Dong, Cuong Dang, Qing Zhang

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引用次数: 1

摘要

本文提出了一种集成等离子体纳米滤波器的荧光图像传感器。读出电路完全集成了高增益像素级电容式反阻抗放大器(CTIA)、列级放大器和相关双采样(CDS)。该纳米滤波器对467 nm激发光和820 nm发射光的模拟抑制比为51 db。考虑到光电二极管量子效率低和干扰，在测量中获得了24.2 db的系统抑制比。此外，有/没有PbS量子点(QDs)的液体样品可以识别22 db的透射率差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Nano-Filter-Integrated CMOS Image Sensor for Fluorescent Biomedical Imaging

This paper presents a fluorescent image sensor with the integrated plasmonic nano-filter using metal layers in CMOS. The readout circuit is fully integrated with a high-gain pixel-level capacitive trans-impedance amplifier (CTIA), column-level amplifier, and correlated double sampling (CDS). The nano-filter achieved 51-dB simulated rejection ratio for 467-nm excitation light and 820-nm emission light. Considering low photodiode quantum efficiency and interference, a 24.2-dB system rejection ratio was achieved in measurement. In addition, liquid samples with/without PbS quantum dots (QDs) can be identified with 22-dB transmittance difference.

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2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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