{"title":"聚酰基化聚赖氨酸树状大分子递送磷酸氯喹","authors":"D. Bhadra, S. Bhadra, N. K. Jain","doi":"10.1109/ICMENS.2004.123","DOIUrl":null,"url":null,"abstract":"The antimalarial drugs are used for prophylactic suppressive chemotherapy of malaria but various toxicity and resistance problems associated with such chemotherapy need some sustained delivery and safer carriers. Dendrimers are recently reported as carriers for various chemotherapeutic agents. Their structures are of regular repeated molecular architecture. Due to number of – NH2 group and charged species like carbonyl groups available on dendritic structures there is huge possibilities for drug loading and drug delivery and further their chemical architecture increases stability of such carriers as compared to other conventional carriers like liposomes, nanoparticles and microparticles. The present work was undertaken to solubilize and load model drug Chloroquine phosphate (CP) and reduce drawbacks of simple drug administration.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"111 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"PEGylated-poly-l-lysine Dendrimers for Delivery of Chloroquine Phosphate\",\"authors\":\"D. Bhadra, S. Bhadra, N. K. Jain\",\"doi\":\"10.1109/ICMENS.2004.123\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The antimalarial drugs are used for prophylactic suppressive chemotherapy of malaria but various toxicity and resistance problems associated with such chemotherapy need some sustained delivery and safer carriers. Dendrimers are recently reported as carriers for various chemotherapeutic agents. Their structures are of regular repeated molecular architecture. Due to number of – NH2 group and charged species like carbonyl groups available on dendritic structures there is huge possibilities for drug loading and drug delivery and further their chemical architecture increases stability of such carriers as compared to other conventional carriers like liposomes, nanoparticles and microparticles. The present work was undertaken to solubilize and load model drug Chloroquine phosphate (CP) and reduce drawbacks of simple drug administration.\",\"PeriodicalId\":344661,\"journal\":{\"name\":\"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)\",\"volume\":\"111 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-08-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/ICMENS.2004.123\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICMENS.2004.123","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
PEGylated-poly-l-lysine Dendrimers for Delivery of Chloroquine Phosphate
The antimalarial drugs are used for prophylactic suppressive chemotherapy of malaria but various toxicity and resistance problems associated with such chemotherapy need some sustained delivery and safer carriers. Dendrimers are recently reported as carriers for various chemotherapeutic agents. Their structures are of regular repeated molecular architecture. Due to number of – NH2 group and charged species like carbonyl groups available on dendritic structures there is huge possibilities for drug loading and drug delivery and further their chemical architecture increases stability of such carriers as compared to other conventional carriers like liposomes, nanoparticles and microparticles. The present work was undertaken to solubilize and load model drug Chloroquine phosphate (CP) and reduce drawbacks of simple drug administration.