欠发达地区低成本便携式呼吸机设计

Rui Wang, Fangzhou Xia
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引用次数: 0

摘要

冠状病毒病(COVID-19)大流行在许多方面给世界带来了重大挑战,特别是对医疗部门。最重要的挑战之一是COVID-19治疗的呼吸机短缺。2020年,全球有近1亿人感染,其中至少10%的患者可能出现严重呼吸窘迫,需要使用呼吸机进行治疗。由于传统呼吸机是不常用的高端医疗设备,随着病例的增加,库存不足。例如,在大流行开始时,美国约有2000人共用一个呼吸机。这种短缺在中非共和国等欠发达国家更为严重,数百万人需要共用一个呼吸机。另一方面,呼吸机对于提高危重患者的存活率至关重要。由于冠状病毒损害肺功能并阻碍氧气吸收,呼吸机通过向肺部加压空气以维持血氧浓度来辅助呼吸。现有的呼吸机不是为应对大流行而设计的,特别是在第三世界国家。高端呼吸机每套的成本通常超过10美元,而且不容易生产。在低端,袋式阀面罩(BVM)需要手动泵送,感染风险很高。麻省理工学院的研究人员开发了基于bvm的自动呼吸机。然而,以前的设计仍然缺少患者生物识别传感和医生报警的重要功能。在这张海报中,我们提出了解决这一挑战的方案,即开发一种低成本的便携式呼吸机,主要有三个亮点。首先,在300美元的目标预算下,该系统可以大量生产,供临时移动小屋医院使用。其次,病人的血氧和心电图监测系统包括无线报警器,以通知医生在紧急情况下。第三,呼出的空气经过专门的过滤器消毒,减少交叉感染的风险。供氧机械子系统的设计以一个由步进电机驱动的机构压缩的BVM为中心。补充氧气也可以从便携式罐中添加。电气子系统主要基于Arduino微控制器平台,用于供氧控制和传感器信号处理。一个定制的仪器放大器为基础的心电图电路和红外血氧计传感器的设计,以测量患者的生物特征。利用蓝牙模块实现远程监控的无线通信方案,可作为对医生的报警。组装好的样机目前可以为肺容量为6000毫升的正常成年人提供氧气,还可以通过远程监控进行心率和血氧浓度的简单测量。正在进行的任务包括选择呼出气体消毒过滤器和处理信号以识别异常的生物特征。还计划进行更多的工作,以提高电池操作设计的可移植性。我们希望这种价格合理的开源设计能够帮助不发达国家克服当前的挑战,为未来的大流行病危机做好更好的准备。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Low-cost Portable Ventilator Design for Underdeveloped Regions
The coronavirus disease (COVID-19) pandemic has significantly challenged the world in many ways especially for the medical sector. One of the most important challenge is the shortage of ventilators for COVID-19 treatment. In 2020, nearly one hundred million people have been infected globally, where at least ten percent of the patients may develop severe respiratory distress that require ventilators for treatment. Since conventional ventilators are high-end medical equipment not commonly used, the stock numbers are insufficient as cases surge. For example, around 2000 people share one ventilator in the U.S at the beginning of the pandemic. Such a shortage is even severer in underdeveloped countries such as the Central African Republic where millions of people need to share a single ventilator. On the other hand, ventilators are vital to increase the survival rate of patients in critical conditions. As the coronavirus damages lung function and impedes oxygen absorption, ventilators assist breathing by pressurizing air into lungs to maintain the blood oxygen concentration. Existing ventilators are not designed for handling the pandemic especially in third-world countries. High-end ventilators typically cost more than $\$10\text{k}$ per installment and cannot be easily produced. On the lower-end, Bag Valve Mask (BVM) requires manual pumping that yields high risk of infection. Researchers at MIT has developed automated BVM-based ventilator. However, the important functionalities for patient biometric sensing and doctor alarming are still missing from previous designs. In this poster, we present our solution to this challenge by developing a low-cost portable ventilator with three main highlights. First, with $\$300$ target budget, the system can be produced in large quantities for use at temporary mobile cabin hospitals. Second, a patient monitoring system for blood oxygen and electrocardiogram are included with wireless alarms to notify doctors in case of emergency. Third, the exhaled air will be disinfected by specialized filter to reduce the risk of cross infection. The oxygen supply mechanical subsystem design is centered around a BVM compressed using a mechanism driven by a stepper motor. Supplemental oxygen can also be added from portable canisters. The electrical subsystems are primarily based on the Arduino microcontroller platform for both oxygen supply control and sensor signal processing. A custom instrumentation-amplifier-based electrocardiogram circuit and an infrared oximeter sensor are designed to measure patient biometrics. A wireless communication scheme is realized with Bluetooth modules for remote monitoring and can operate as an alarm to the doctor. The assembled prototype is currently capable of supplying oxygen to normal adults with a lung capacity of 6000 ml. It can also conduct simple measurement of heart rate and blood oxygen concentration with remote monitoring. The on-going tasks involve selecting exhaled gas disinfecting filter and processing signals to identify abnormal biometrics. Additional work on improving the portability of the design with battery operation is also planned. We hope this affordable opensource design can help underdeveloped countries overcome the current challenges and be better prepared for future pandemic crisis.
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