Hanif Benazir Salsabillah Gani, Samad R, Julyani S, R. Muhiddin
{"title":"ABO血型与COVID-19患者病情严重程度、住院时间及死亡率的关系","authors":"Hanif Benazir Salsabillah Gani, Samad R, Julyani S, R. Muhiddin","doi":"10.24293/ijcpml.v29i2.1988","DOIUrl":null,"url":null,"abstract":"Previous research suggests that the ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 virus infection. The purpose of this study was to analyze the relationship between the ABO blood group and the severity, length of hospitalization, and mortality rate of COVID-19. A descriptive-analytic study with a cohort retrospective design, involving 257 research samples, was conducted. The statistical tests used in this research were the Kolmogorov-Smirnov test, the Chi-Square test, the Fisher Exact test, and the Kruskal-Wallis test. The test results were significant if the p-value <0.05. From the results of the study, it was found that the analysis of blood type with severity was not statistically significant (p> 0.05), as well as blood type with severity and length of treatment, there was no relationship between severity and length of stay in all blood groups (all with p>0.05) while for blood groups with severity and mortality, there was a relationship between blood type and high mortality in all blood groups (all with p<0.001). There was no relationship between blood type and severity of SARS-CoV-2 virus infection (all p>0.05). However, there was a significant relationship between criticality and high mortality in all blood groups (all with p<0.001). Pathophysiological mechanisms that explain the relationship between ABO blood type and SARS-CoV-2 infection, one of which is the presence of anti-A antibodies in group O individuals that bind to the A antigen in the viral envelope and block infection, in which blood group O has susceptibility to SARS virus infection. There is no relationship between ABO blood type and patient severity and length of stay, but there is a correlation between mortality and ABO blood type in COVID-19 patients.","PeriodicalId":354500,"journal":{"name":"Indonesian Journal of Clinical Pathology and Medical Laboratory","volume":"11 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship between ABO Blood Group with Severity, Length of Hospitalization, and Mortality Rate of COVID-19 Patients\",\"authors\":\"Hanif Benazir Salsabillah Gani, Samad R, Julyani S, R. Muhiddin\",\"doi\":\"10.24293/ijcpml.v29i2.1988\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Previous research suggests that the ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 virus infection. The purpose of this study was to analyze the relationship between the ABO blood group and the severity, length of hospitalization, and mortality rate of COVID-19. A descriptive-analytic study with a cohort retrospective design, involving 257 research samples, was conducted. The statistical tests used in this research were the Kolmogorov-Smirnov test, the Chi-Square test, the Fisher Exact test, and the Kruskal-Wallis test. The test results were significant if the p-value <0.05. From the results of the study, it was found that the analysis of blood type with severity was not statistically significant (p> 0.05), as well as blood type with severity and length of treatment, there was no relationship between severity and length of stay in all blood groups (all with p>0.05) while for blood groups with severity and mortality, there was a relationship between blood type and high mortality in all blood groups (all with p<0.001). There was no relationship between blood type and severity of SARS-CoV-2 virus infection (all p>0.05). However, there was a significant relationship between criticality and high mortality in all blood groups (all with p<0.001). Pathophysiological mechanisms that explain the relationship between ABO blood type and SARS-CoV-2 infection, one of which is the presence of anti-A antibodies in group O individuals that bind to the A antigen in the viral envelope and block infection, in which blood group O has susceptibility to SARS virus infection. There is no relationship between ABO blood type and patient severity and length of stay, but there is a correlation between mortality and ABO blood type in COVID-19 patients.\",\"PeriodicalId\":354500,\"journal\":{\"name\":\"Indonesian Journal of Clinical Pathology and Medical Laboratory\",\"volume\":\"11 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indonesian Journal of Clinical Pathology and Medical Laboratory\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24293/ijcpml.v29i2.1988\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indonesian Journal of Clinical Pathology and Medical Laboratory","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24293/ijcpml.v29i2.1988","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Relationship between ABO Blood Group with Severity, Length of Hospitalization, and Mortality Rate of COVID-19 Patients
Previous research suggests that the ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 virus infection. The purpose of this study was to analyze the relationship between the ABO blood group and the severity, length of hospitalization, and mortality rate of COVID-19. A descriptive-analytic study with a cohort retrospective design, involving 257 research samples, was conducted. The statistical tests used in this research were the Kolmogorov-Smirnov test, the Chi-Square test, the Fisher Exact test, and the Kruskal-Wallis test. The test results were significant if the p-value <0.05. From the results of the study, it was found that the analysis of blood type with severity was not statistically significant (p> 0.05), as well as blood type with severity and length of treatment, there was no relationship between severity and length of stay in all blood groups (all with p>0.05) while for blood groups with severity and mortality, there was a relationship between blood type and high mortality in all blood groups (all with p<0.001). There was no relationship between blood type and severity of SARS-CoV-2 virus infection (all p>0.05). However, there was a significant relationship between criticality and high mortality in all blood groups (all with p<0.001). Pathophysiological mechanisms that explain the relationship between ABO blood type and SARS-CoV-2 infection, one of which is the presence of anti-A antibodies in group O individuals that bind to the A antigen in the viral envelope and block infection, in which blood group O has susceptibility to SARS virus infection. There is no relationship between ABO blood type and patient severity and length of stay, but there is a correlation between mortality and ABO blood type in COVID-19 patients.