生物医学网络的链路预测

Chau Pham, Tommy Dang
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引用次数: 4

摘要

网络数据集在许多领域随处可见,如蛋白质相互作用、论文引用和社交网络。虽然有些网络是定义良好的,但其他许多网络则没有。例如,系统生物学家和医学研究人员仍在研究癌症途径中蛋白质的相互作用。因此,在这些网络上执行的主要分析任务之一是链接预测,我们希望以一定的置信度揭示一些未知的关系。在本文中,我们使用最先进的图神经网络在生物医学领域的网络数据集上进行了一些实验。结果表明,实体值有助于基于图的模型在揭示生物医学研究中的潜在关系方面表现良好,并有可能扩展到其他应用领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Link Prediction for Biomedical Network
Network datasets are seen ubiquity in many fields, such as protein interactions, paper citation, and social networks. While some networks are well-defined, many others are not. For example, the interactions of proteins in cancer pathways are still studied by system biologists and medical researchers. Therefore, one of the primary analytic tasks to perform on these networks is link prediction, where we desire to reveal some unknown relationships with certain levels of confidence. In this paper, we carry out some experiments on network datasets in the biomedical domain using state-of-the-art Graph Neural Networks. The results show that entity’s values facilitate graph-based models to perform well on uncovering latent relationships in biomedical research and potentially be extended on other application domains.
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