{"title":"第三章。步骤，累积和全局e因子和过程质量强度指标的应用，以衡量合成效率:左旋多巴和阿哌沙班药物的例子","authors":"J. Andraos","doi":"10.1039/9781788016131-00039","DOIUrl":null,"url":null,"abstract":"The utility of step, cumulative, and global E-factor and process mass intensity metrics is demonstrated for the analysis of the material efficiency of synthesis plans for the pharmaceuticals l-DOPA and apixaban. The mathematical relationships relating global and cumulative metrics to step metrics are applicable to any synthesis plan for any molecule.","PeriodicalId":202204,"journal":{"name":"Green Chemistry Series","volume":"18 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"CHAPTER 3. Application of Step, Cumulative, and Global E-factor and Process Mass Intensity Metrics to Gauge Synthesis Efficiency: l-DOPA and Apixaban Pharmaceutical Examples\",\"authors\":\"J. Andraos\",\"doi\":\"10.1039/9781788016131-00039\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The utility of step, cumulative, and global E-factor and process mass intensity metrics is demonstrated for the analysis of the material efficiency of synthesis plans for the pharmaceuticals l-DOPA and apixaban. The mathematical relationships relating global and cumulative metrics to step metrics are applicable to any synthesis plan for any molecule.\",\"PeriodicalId\":202204,\"journal\":{\"name\":\"Green Chemistry Series\",\"volume\":\"18 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Green Chemistry Series\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/9781788016131-00039\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Chemistry Series","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/9781788016131-00039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
CHAPTER 3. Application of Step, Cumulative, and Global E-factor and Process Mass Intensity Metrics to Gauge Synthesis Efficiency: l-DOPA and Apixaban Pharmaceutical Examples
The utility of step, cumulative, and global E-factor and process mass intensity metrics is demonstrated for the analysis of the material efficiency of synthesis plans for the pharmaceuticals l-DOPA and apixaban. The mathematical relationships relating global and cumulative metrics to step metrics are applicable to any synthesis plan for any molecule.
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