自然暴露于疟疾个体对间日疟原虫TRAP蛋白合成抗原和重组抗原的体液反应评价

Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI:10.35259/isi.sact.2019_32533

Ada da Silva Matos, Rodrigo Silva, I. F. Soares, Barbara de Oliveira Baptista, P. Totino, C. Daniel-Ribeiro, C. Camacho, A. Reyes‐Sandoval, L. R. Pratt-Riccio, Josué da Costa Lima Junior

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引用次数: 0

摘要

疟疾寄生虫的血栓相关黏附蛋白(TRAP)对孢子子运动和侵入蚊子唾液腺和脊椎动物肝细胞至关重要。由于这一重要性，它是红细胞前疫苗的一个有希望的靶点。尽管关于间日疟原虫TRAP (PvTRAP)的自然获得性免疫反应的报道很少，但结果是相互矛盾的，并且在亚马逊地区的探索很少。

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Evaluation of humoral response of individuals naturally exposed to malaria against synthetic and recombinant antigens representing Plasmodium vivax TRAP protein

Introduction: Thrombospondin-related adhesive protein (TRAP) of malaria parasites is essential for sporozoite motility and invasions into mosquito’s salivary gland and vertebrate’s hepatocyte. Due this importance, it is a promising target for pre-erythrocytic vaccine. Despite few reports on naturally acquired immune response against Plasmodium vivax TRAP (PvTRAP) are available, the results are conflicting and poorly explored in the Amazon region.

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Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos

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