肌醇和硫辛酸对PCOs患者的辅助及临床作用

P. Juan, Perruzza Marta, Donfrancesco Cristina, R. Giuseppe
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摘要

背景:多囊卵巢综合征(PCOs)是绝经前妇女最常见的内分泌代谢疾病之一。我们的团队旨在通过超声评估和随访临床分析,了解基于α硫辛酸(ALA)/肌醇(Myo)联合药物治疗对附件参数的最终显著影响。方法:以下是一项前瞻性试验的结果,该试验考虑了从58名妇女的初始组中选择的30名意大利未生育妇女的数据,并将其与按年龄和未生育状况配对的健康妇女组的数据进行了比较。平均年龄为30.1岁。患者接受肌醇(400毫克)加ALA(800毫克)方案,每天两次,持续24个月。超声检查与月经第5天同时进行,时间设置如下:时间0(第一次评估),时间12(12个月后),时间24(24个月后)。结果:比较时间0和时间12的配对数据,配对患者在试验时子宫内膜宽度、卵泡数量、卵巢体积等超声参数均无显著差异。临床症状方面,经期盆腔疼痛平均约4个月后明显减轻,经治疗8个月后,30例患者中有12例月经周期趋于正常。处理超声彩色多普勒测速状态的参数考虑到其他十二个月进行了研究,并将在进一步的报告中描述仅考虑超声参数。结论:考虑到本研究的初步结果,我们可以假设肌醇可能阻断了肾上腺素增生性的血管作用,ALA也可能在抗氧化和抗炎途径中发挥作用
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adnexal and clinical effects of myoinositol and lipoic acid in PCOs patients
Background: Polycistic ovary syndrome (PCOs) is one of the most common endocrine and metabolic disorders in premenopausal women. Our team aimed to know an eventual significant effect of the therapy based on an Alfa Lipoic Acid (ALA)/Myoinositol (Myo) combined drug on adnexal parameters as assessed by ultrasound and follow up clinical analysis. Methods: The following represents the results of a prospective trial considering data from thirty italian nulliparous women considered for the study, chosen from an initial group of fifty-eight women, compared to data taken from a healthy women group paired by age and nulliparous status. The mean age was 30.1 years old. Patients underwent a Myoinositol (400 mg) plus ALA (800 mg) regimen twice a day in a continued fashion in a twenty four months period. Ultrasound examinations were coincident with the fifth day of menstrual period and were set as follows: Time 0 (first evaluation), Time 12 (after twelve months) and finally Time 24 (after 24 months). Results: Comparisons were performed between Time 0 and Time 12 paired data, No significant ultrasound parameters differences were found between paired patients regarding: endometrial width, number of follicles and ovarian volume at the time of the trial. Regarding clinical symptoms, menstrual pelvic pain significantly decreased after a mean time of about four months and menstrual cycle tended to be regular in 12 from 30 patients after eight months under therapy. Parameters dealing with ultrasound color Doppler velocimetry status were studied considering other twelve months and will be described in a further report considering only ultrasound parameters. Conclusions: Considering the preliminary results of this study, we may hypothesize that Inositol may block the vascular effects of hyperadrogenism, and that the ALA in addition may play a role regarding anti oxidant and anti inflammatory pathways
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