冠状动脉旁路移植术术后早期双重任务认知康复患者的电流源密度(sLORETA

I. Tarasova, D. Kupriyanova, O. Trubnikova, I. Kukhareva, A. Sosnina, S. B. Ten, V. G. Shesternin, O. Barbarash
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Data processing of EEG background activity for sLORETA analysis was performed using the EEGLAB in MATLAB software (The MathWorks, Natick, MA, USA). The sLORETA algorithms were used to calculate dynamic cross spectrum and current source density within the analyzed frequency range (4–6 Hz). Statistical analysis of current source density indicators was carried out by using the method of statistical non-parametric mapping in the sLORETA software package, and the difference between the current source density in the pre- and postoperative period (after cognitive rehabilitation) was calculated as well.Results. Cognitive rehabilitation was successful in 44% (7 patients) of cases. The differences have been revealed between the groups with successful and unsuccessful cognitive rehabilitation by using sLORETA. 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引用次数: 0

摘要

高光。首次采用标准化低分辨率电磁断层扫描(sLORETA)方法,对心脏手术中认知康复成功的神经生理学相关因素进行评估。成功康复的患者术后右半球静息状态θ波活动值较低,提示转移效应,这是认知康复成功的重要组成部分。脑缺血的可视化和监测对脑血管疾病的诊断具有重要意义。本研究的目的是评估标准化低分辨率电磁脑断层扫描(sLORETA)方法的可能性和适用性,以分析在心脏手术相关的缺血中使用双重任务进行认知康复以恢复受损脑功能的患者的脑电活动。该研究包括16名男性患者(45-75岁),他们在心血管疾病复杂问题研究所的诊所接受了计划中的冠状动脉旁路移植术(CABG)。术前2 ~ 3天和术后1周分别进行临床和神经生理检查。所有患者从术后第3天或第4天开始进行认知康复,并持续到出院,并评估结果。单极脑电图(62通道)在闭眼坐着休息时记录,使用Neuvo SynAmps2放大器隔绝光线和噪音。使用MATLAB软件(the MathWorks, Natick, MA, USA)中的EEGLAB对EEG背景活动进行数据处理,以进行sLORETA分析。采用sLORETA算法计算分析频率范围(4 ~ 6 Hz)内的动态交叉频谱和电流源密度。采用sLORETA软件包中的统计非参数映射法对电流源密度指标进行统计分析,并计算术前与术后(认知康复后)电流源密度的差值。7例患者的认知康复成功率为44%。结果表明,应用斯洛雷塔治疗认知康复成功组与不成功组之间存在差异。与康复成功组相比,认知康复失败组在θ波节律中显示出更高的电流源密度估计,最明显(t>- 8.42;p<0.004)右半球- Brodmann区22,颞叶和颞上回。sLORETA方法证实了认知训练对非泵式冠脉搭桥患者脑活动空间模式变化的积极影响。认知康复成功与术后右半球静息状态θ波活动降低相关,表明转移效应,这是认知康复成功的重要组成部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current source density (sLORETA) in patients undergoing cognitive rehabilitation using dual task in the early postoperative period of coronary artery bypass grafting
Highlights. For the first time, the method of standardized low resolution electromagnetic tomography – sLORETA was used to assess the neurophysiological correlates of the success of cognitive rehabilitation using dual task to recover the brain functions affected by ischemia during cardiac surgery.The patients who were successfully rehabilitated have demonstrated lower postoperative values of resting state theta activity within the right hemisphere, indicating the transfer effect, which is an important component of successful cognitive rehabilitation.Aim. Visualization and monitoring of brain ischemia is important for the diagnosis of cerebrovascular diseases. The aim of the study was to evaluate the possibilities and applicability of the method of standardized low resolution electromagnetic brain tomography – sLORETA for analyzing brain electrical activity in patients undergoing cognitive rehabilitation using dual tasks to recover impaired brain functions during ischemia associated with cardiac surgery.Methods. The study included 16 male patients (45–75 years old) who were admitted for planned coronary artery bypass grafting (CABG) to the Clinic at the Research Institute for Complex Issues of Cardiovascular Diseases. Clinical and neurophysiological examinations were performed 2–3 days before CABG and 1 week after surgery. All patients underwent cognitive rehabilitation that started at postoperative day 3 or 4 and lasted until discharge, the outcome was assessed as well. Monopolar EEG (62 channels) was recorded at rest in a sitting position with eyes closed in a light- and noise-insulated room using a Neuvo SynAmps2 Amplifier. Data processing of EEG background activity for sLORETA analysis was performed using the EEGLAB in MATLAB software (The MathWorks, Natick, MA, USA). The sLORETA algorithms were used to calculate dynamic cross spectrum and current source density within the analyzed frequency range (4–6 Hz). Statistical analysis of current source density indicators was carried out by using the method of statistical non-parametric mapping in the sLORETA software package, and the difference between the current source density in the pre- and postoperative period (after cognitive rehabilitation) was calculated as well.Results. Cognitive rehabilitation was successful in 44% (7 patients) of cases. The differences have been revealed between the groups with successful and unsuccessful cognitive rehabilitation by using sLORETA. The group with unsuccessful cognitive rehabilitation demonstrated higher current source density estimates in theta rhythm compared with the successful rehabilitation group, it was most pronounced (t>- 8.42; p<0.004) in the right hemisphere – Brodmann area 22, temporal lobe and superior temporal gyrus.Conclusion. The sLORETA method demonstrated the positive effect of cognitive training on changes in the spatial patterns of brain activity in patients undergoing onpump CABG. The successful cognitive rehabilitation was associated with lower postoperative resting state theta activity within the right hemisphere, indicating the transfer effect, which is an important component of successful cognitive rehabilitation.
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