全身炎症反应是乳腺癌的预后因素。第一部分:促肿瘤炎症。血清炎症标志物

N. Sergeeva, T. Karmakova, M. A. Polyak, I. Alentov, A. Kaprin
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引用次数: 0

摘要

暴露于外部或内部因素引起的慢性炎症增加了发生恶性肿瘤的风险,并由于对致癌机制的关键要素的影响而促进肿瘤进展。在系统水平上,慢性炎症的症状表现为血液中炎症介质和急性期蛋白水平的增加,循环白细胞群比例的变化以及止血系统的紊乱。本文综述了乳腺癌(BC)的全身炎症反应(SIR)的血清和血液学参数。综述的第一部分概述了炎症因子在恶性肿瘤发展中的作用的一般概念。它提供了乳腺癌中研究最充分的血清炎症标志物的信息:细胞因子,包括白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)、肿瘤坏死因子- α (TNF-)以及c反应蛋白(CRP)。考虑了这些多肽的主要特性,它们与促进肿瘤的炎症有关。本文对迄今积累的乳腺癌患者血清细胞因子和CRP水平的临床意义进行了分析。血清炎症标志物水平升高与疾病的临床和形态学特征、肿瘤对化疗的反应、患者的总生存期和无复发生存期之间的相关性表明,为了在BC中实际应用全身炎症标志物作为预测和预后指标,对该问题进行深入研究是可行的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Systemic Inflammatory Response as a Prognostic Factor in Breast Cancer. Part I. Tumor-Promoting Inflammation. Serum Inflammatory Markers
Chronic inflammation caused by exposure to external or internal factors increases the risk of developing malignancies and promotes tumor progression due to the influence on the key elements of carcinogenic mechanisms. At the system level signs of a chronic inflammation are manifested by an increase of inflammatory mediators and acute phase proteins levels in the blood, a change in the ratio of circulating leukocyte populations, and disturbances in the hemostasis system. This review is devoted to serum and hematological parameters of the systemic inflammatory response (SIR) in breast cancer (BC). The first part of the review outlines general concept about the role of inflammatory factors in the development of malignant tumors. It provides information on the most well studied serum inflammatory markers in breast cancer: cytokines, including interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-), as well as C-reactive protein (CRP). The main properties of these polypeptides, which link them with tumor-promoting inflammation, are considered. An analysis of the data on the clinical significance of the serum level of cytokines and CRP in breast cancer accumulated to date is presented. Correlations of the elevated levels of the serum inflammatory markers with clinical and morphological characteristics of the disease, tumor response to chemotherapy, overall and relapse-free survival of patients indicate the feasibility of in-depth investigation of the issue for the purpose of the practical application of the systemic inflammatory markers as predictive and prognostic indicators in BC.
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