风湿病患儿的合并症:文献综述和10年自身研究经验

L. Bogmat, N. Shevchenko, T. Holovko, V. Nikonova, I. Bessonova, E.L. Akhnazariants, A.O. Fadieieva
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摘要

背景。儿童风湿性疾病发病年龄的下降,疾病总持续时间的增加,器官和系统持续功能和器质性紊乱的发展,决定了有必要研究儿童时期已经存在的合并症,以便优化其诊断和综合治疗。目的是研究风湿性疾病(幼年特发性关节炎(JIA)和系统性红斑狼疮(SLE))患儿合并症的发生频率和主要模式。材料和方法。对成人风湿病患者和儿童共病病变的患病率和诊断的文献进行了分析性回顾;动态监测250例3-18岁JIA患儿和67例幼年起病SLE患儿是否存在心血管系统、肾脏、肺、眼睛、骨组织、血脂紊乱等合并症。结果。JIA和SLE患儿共病的频率和性质已经确定。过程活性的保存是共病病理进展的主要因素,随着器官和系统衰竭的发展和患者生活质量的破坏,对器官和系统形成不可逆转的损害。结论。基于所提供的材料,有可能制定计划,以防止在风湿病患儿共病条件下发生的系统和器官的不可逆损伤的形成和进展,并有效地使这些儿童社会化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comorbidity in children with rheumatic diseases: literature review and 10-year experience of own research
Background. A decrease in the age of onset of rheumatic diseases in children, an increase in the total duration of the disease, the development of persistent functional and organic di­sorders of organs and systems determine the need to study comorbid conditions already in childhood in order to optimize their diagnosis and comprehensive therapy. The purpose was to study the frequency and main patterns for the formation and further progression of comorbidities in children with rheumatic diseases (juvenile idiopathic arthritis (JIA) and systemic lupus erythematosus (SLE)). Materials and methods. An analytical review of the literature on the prevalence and diagnosis of comorbid lesions in adult patients with rheumatic diseases and in children was carried out; 250 children aged 3–18 years with JIA and 67 children with SLE with a juvenile onset were dynamically monitored for the presence of comorbid conditions of the cardiovascular system, kidneys, lungs, eyes, bone tissue, blood lipid disorders. Results. The frequency and nature of comorbidity in children with JIA and SLE have been determined. Preservation of the process activity is the main factor in the progression of comorbid pathology and the formation of irreversible damage to organs and systems with the development of their failure and violations of the quality of life of patients. Conclusions. Based on the presented materials, it is possible to develop programs to prevent the formation and progression of irreversible damage to systems and organs that occur under comorbid conditions in children with rheumatic diseases and to effectively socialize these children.
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