针刺治疗慢性前列腺炎的外周神经刺激:个案研究

Hervik J, Stub T
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引用次数: 0

摘要

慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)定义为持续至少3个月的慢性盆腔疼痛,常伴有下尿路症状和/或性功能障碍[1]。前列腺炎是一种常见的疾病,35-50%的男性在其一生中受到前列腺炎症状的影响。它与负面的心理影响和大量的医疗费用有关[2]。目前有许多治疗方法,使用药物和非药物干预,尽管缺乏证据表明这些治疗方法的有效性。一项系统综述[3]检查了16种不同的CP/CPPS药物治疗的证据。99项研究包括9119名男性。治疗方法包括α -受体阻滞剂、5- α还原酶抑制剂、抗生素、抗炎药、别嘌呤醇和肉毒杆菌毒素注射。作者发现低质量到极低质量的证据表明,这些干预措施可以减少前列腺炎症状,短期内没有增加不良事件的发生率。他们报告说,缺乏证据表明这些药物对性功能障碍、生活质量或焦虑和抑郁的影响。通过对10项已发表试验(n=770)的系统回顾和荟萃分析[4],研究了针刺对CP/CPPS的疗效。分析显示,与标准药物相比,针灸显著降低了美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分,并提供了疼痛缓解,与假药相比,针灸减轻了症状。四次针刺是达到临床疗效的最小“剂量”,延长针刺时间可持续改善泌尿系统症状和生活质量。外周神经刺激(PNS)是治疗慢性疼痛的有效手段。与前几代相比,侵入性更小的小型化设备使这种治疗方式成为主流。最近的临床证据表明,临床显著和持续的疼痛减轻可以持续到PNS治疗期之后[5]。针刺是一种微创治疗PNS的方法。针刺点位于主要神经束上,与主要神经的皮支相关[6]。这些神经在脊髓水平汇聚并与内脏伤害性输入相互作用。这种解剖学上的相关性为针灸应用于特定区域可以治疗多种疾病提供了基础,如前列腺炎,远离治疗部位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acupuncture Used as a Method of Peripheral Nerve Stimulation in Chronic Prostatitis: A Case Study
Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is defined as chronic pelvic pain lasting for at least 3 months, often associated with lower urinary tract symptoms and/or sexual dysfunction [1]. Prostatitis is a common condition, with 35–50% of men affected by symptoms suggesting prostatitis during their lifetime. It is associated with negative psychological effects and substantial health care costs [2]. There are currently many approaches for its management, using both pharmacological and non‐pharmacological interventions, though there is a lack of evidence for the efficacy of these treatments. A systematic review [3] examined the evidence for 16 different pharmacological treatments of CP/CPPS. Ninety-nine studies included 9119 men. Treatment approaches included alpha-blockers, 5-alpha reductase inhibitors, antibiotics, anti-inflammatories, allopurinol and botulinum toxin injections. The authors found low‐ to very low‐quality evidence that these interventions cause a reduction in prostatitis symptoms, without an increased incidence of adverse events in the short term. They reported lack of evidence regarding the effects of these drugs on sexual dysfunction, quality of life, or anxiety and depression. The efficacy of acupuncture on CP/CPPS was examined in a systematic review and meta-analysis [4] of 10 published trials (n=770). Analysis revealed that acupuncture significantly reduced the National Institute of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) score and provided pain relief, compared to standard medication, and reduced symptoms when compared to sham. Four acupuncture sessions were the minimum “dose” to reach clinical efficacy, and prolonged acupuncture sessions continuously improved urinary symptoms and quality of life. Peripheral Nerve Stimulation (PNS) is an effective tool for the treatment of chronic pain. Miniaturized devices that are less invasive than previous generations has brought this treatment modality into mainstream use. Recent clinical evidence suggests clinically significant and sustained reductions in pain can persist well beyond the PNS treatment period [5]. Acupuncture is a minimally invasive method of PNS. Acupuncture points have been shown to overlie major neuronal bundles, which correlate with cutaneous branches of major nerves [6]. These nerves converge and interact with visceral nociceptive inputs at the spinal cord level. This anatomical correlation provides the basis on which acupuncture applied to a specific region could treat a variety of conditions such as prostatitis, remote to the site of treatment.
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