后丘脑底区深部脑刺激治疗腹侧丘脑中间核切开术后复发性震颤1例

Seung Un Lee, Na Young Jung
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摘要

神经外科治疗被认为是原发性震颤(ET)患者的有效治疗选择,因为大约50%的ET患者对药物治疗难治性[1]。从历史上看,从烧蚀手术到深部脑刺激(DBS),各种方法都被使用,每种方法都有自己的优缺点。随着近年来磁共振引导聚焦超声(FUS)技术的发展,ET的病变处理出现了新的趋势[2]。虽然每种治疗方法可以相互补充,但临床医生在决定使用哪种手术技术或需要对哪个靶点进行第二次治疗时不可避免地面临困难。在损伤手术后复发的病例中,不确定刺激先前损伤的神经结构是否能达到同样的控制震颤的效果。此外,在DBS过程中,由于丘脑瘢痕形成,设置颅内手术束不舒服。相比之下,在DBS失败后,用电气设备消融附近区域可能会造成非常沉重的损害。在此,我们报告了一例丘脑腹侧中间核(VIM)消融后复发性震颤的病例,该病例通过丘脑后底区(PSA) DBS有效地治疗,并回顾了以往有类似经验的报道。后丘脑底区深部脑刺激治疗腹侧丘脑中间核切开术后复发性震颤1例
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Posterior subthalamic area deep brain stimulation for recurrent tremor after ventral intermediate nucleus thalamotomy: a case report
Neurosurgical treatment is considered as an effective treatment option for patients with essential tremor (ET), since approximately 50% of the ET population is refractory to medical treatment [1]. Historically, various methods, from ablative procedures to deep brain stimulation (DBS) have been used, each having its own strengths and weaknesses. With the recent development of magnetic resonance guided focused ultrasound (FUS), a new trend in the lesioning procedure for ET has emerged [2]. Although each treatment can be complementary to each other, clinicians inevitably face difficulties in deciding which surgical technique to use or which target needs to be operated on for the second treatment. In recurrent case after lesioning procedure, it is uncertain whether stimulating previously injured neural structures can achieve the same effectiveness to control tremor. Moreover, it is uncomfortable to set the intracranial surgical tract due to thalamic scarring during the DBS. In contrast, lesioning after failed DBS can be very burdensome to ablate nearby areas with electrical devices. Here, we present a case of recurrent tremor after ablation of the ventral intermediate nucleus of the thalamus (VIM), which was effectively managed with posterior subthalamic area (PSA) DBS, and review previous reports with similar experiences. Posterior subthalamic area deep brain stimulation for recurrent tremor after ventral intermediate nucleus thalamotomy: a case report
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