症状性蛛网膜炎骨化伴脊髓空洞:一例临床病例及简要文献回顾

R. A. Kovalenko, N. V. Osipova, V. A. Mineev, L. Mitrofanova
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摘要

目标。本文报道1例骨化性蛛网膜炎合并脊髓空洞症的临床病例,并对其病因、发病机制及诊治方法作简要的文献复习。材料和方法。一个临床病例的68岁患者与症状性蛛网膜炎骨化描述。诊断依据术中活检、切除碎片组织学检查结果,术后行脊髓CT、多层螺旋CT脊髓造影等证实。病理过程分析提出以下问题:诊断标准和最佳治疗策略。本文简要回顾了1982年至今文献报道的骨化性蛛网膜炎病例。对文献中描述的骨化性蛛网膜炎病例的回顾表明,今天没有诊断和治疗这种疾病的单一策略。在大多数病例中,诊断是在术中确定的(65%的分析病例)。在术前阶段,CT提供了可靠的骨化可视化。在选择治疗方法时,应综合考虑临床表现的严重程度、蛛网膜骨化的程度以及受累脊髓部有无伴发病变(如脊髓空洞)。日益严重的神经功能障碍应被认为是骨化性蛛网膜炎患者手术治疗的指征。手术的目标应包括神经结构的减压和恢复正常的脑脊液循环。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Symptomatic arachnoiditis ossificans associated with syringomyelia: a clinical case and a brief literature review
Objective. To present a clinical case of arachnoiditis ossificans associated with syringomyelia and a brief literature review with an emphasis on its etiology, pathogenesis and methods of diagnosis and treatment.Material and Methods. A clinical case of a 68-year-old patient with symptomatic arachnoiditis ossificans is described. The diagnosis was established on the basis of the results of intraoperative biopsy, histological examination of the resected fragment and confirmed in the postoperative period using CT of the spinal cord, multislice CT myelography, etc. Analysis of the course of the pathology raised the following questions: diagnostic criteria and optimal tactics for treating this disease. A brief review of cases of arachnoiditis ossificans described in the literature for the period from 1982 to the present is given.Results. A review of cases of ossifying arachnoiditis described in the literature showed that today there is no single tactic for diagnosing and treating this disease. In most cases, the diagnosis is established intraoperatively (65 % of analyzed cases). At the preoperative stage, CT provides reliable visualization of ossification. When choosing therapy, it is necessary to be based on the severity of the clinical picture, the degree of ossification of the arachnoid membrane and the presence of concomitant pathology of the affected spinal cord department (such as syringomyelia).Conclusion. The presence of a growing neurological deficit should be considered an indication for surgical treatment of patients with arachnoiditis ossificans. The goals of surgery should include decompression of neural structures and restoration of normal cerebrospinal fluid circulation.
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