Masquerade Syndrome: Diagnostic Challenges in a Case of Primary Central Nervous System Lymphoma

The objective of this investigation was to present a case of masquerade syndrome secondary to primary CNS lymphoma in a Northern Ontario community. Masquerade syndrome of primary CNS lymphoma in the eye can often be misinterpreted as an immune-mediated process, owing to its tendency to first present with only vitreous cell, or chronic uveitis. Correct diagnosis of intraocular primary CNS lymphoma requires clinical suspicion and ophthalmologists should have a low threshold for triggering a diagnostic work-up of older and immunocompromised patients with a characteristic presentation.