Identification of the hemodynamic significant patent ductus arteriosus in preterm infants

Objective To review the research on the discernible markers of hemodynamic significant patent ductus arteriosus (hsPDA). Date sources We consulted literatures from PubMed in English up to 2020. Study selection Data about sensitivity, specificity and cut-off value and experimental conclusion are from clinical trials and accurate analysis. Result Hemodynamic significant PDA is associated with severe complications and mortality in premature infant. So far, there are still controversies over the treatment of patent ductus arteriosus in preterm infants, mainly relating to identification of hemodynamic significant patent ductus arteriosus (hsPDA) is ununiform. Numbers of scholars used to employ color Doppler markers to evaluate hsPDA in last 4 decades. This review aims to identify hsPDA in preterm infants from three aspects by analysis the literatures, including non-invasive detection index, biological index and clinical index, which providing evidence-based guidance to reduce the occurrence of excessive medical treatment. Conclusion Echocardiographic markers combining with biological and clinical indicators can improve the identification of hsPDA clinically. Despite the definition of hsPDA has been investigated, the diagnosis and treatment remain ambiguous. More comprehensive and meaningful assessment for hsPDA is required.