小鼠皮质酮的昼夜节律:长期饮酒的影响。

R Kakihana, J A Moore
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引用次数: 55

摘要

长期饮酒对DBA/2J雄性小鼠血浆皮质酮昼夜变化的影响饮酒15周后(第一周3.8%w/v,随后几周7.5%),酒精组表现出平坦的昼夜皮质酮曲线,水平介于水对照组的峰值和低谷值之间。在酒精治疗的第10周,酒精组的食物和液体的每日消耗模式仍然存在,尽管在每个6小时间隔的食物和液体的绝对摄入量在酒精组和水组之间有所不同。血液中酒精含量在清晨达到峰值,平均值为100 mg/100 ml,但其余时间的酒精含量非常稳定,平均值在30至46 mg/100 ml之间。长期饮酒,即使浓度相对较低,似乎也会影响控制ACTH释放昼夜节律的中枢神经系统的神经部位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circadian rhythm of corticosterone in mice: the effect of chronic consumption of alcohol.

The effect of chronic consumption of alcohol on the circadian variations of the plasma corticosterone investigated in DBA/2J male mice. After 15 weeks of alcohol consumption (3.8%w/v for the first week and 7.5% for subsequent weeks) the alcohol groups exhibited a flattened circadian corticosterone curve, the level being intermediate between the peak and trough values of the water control groups. The diurnal patterns of food and liquid consumption were still present at the 10th week of alcohol treatment in the alcohol groups, although the absolute amount of food and liquid consumed at each of the 6-h intervals was somewhat different between the alcohol and water groups. The blood alcohol showed a peak at early morning with the mean of 100 mg/100 ml, but the levels of alcohol during the remaining periods were remarkably stable, the means ranging from 30 to 46 mg/100 ml. Chronic consumption of alcohol, even relatively low concentrations, appears to affect the neural sites in the CNS controlling the circadian rhythm of ACTH release.

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