32通道全定制CMOS生物传感器芯片，用于细胞外神经信号记录

Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Pub Date : 2005-03-16 DOI:10.1109/CNE.2005.1419711

Xin Zhang, J. Daly, Yong Cao

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引用次数: 4

摘要

在本文中，我们提出了一个全定制的CMOS生物传感器集成电路(IC)的设计、布局和实现技术，用于细胞外多通道动作电位记录应用。给出了各子电路宏的原理图和仿真数据，其中包括接触传感器、单位增益缓冲器、变增益放大器和逻辑控制单元。该芯片对幅值在50- 500muv、频谱在20- 2000hz的神经信号提供了满意的信噪比。采用AMI’s 1.5 μ m双聚双能级金属CMOS技术，采用MOSIS技术制作了原型IC

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32-Channel Full Customized CMOS Biosensor Chip for Extracellular Neural Signal Recording

In this paper we present a full-customized CMOS biosensor integrated circuit (IC) design, layout, and implementation techniques for extracellular multichannel action potential recording applications. Schematics and simulation data for each of the sub-circuit macros are presented which includes contact sensors, unity gain buffer, variable gain amplifier and logic control unit. The chip provides a satisfactory signal-to-noise ratio for neural signals with amplitudes in the range of 50-500 muV and frequency spectrum in the range of 20-2000 Hz. The prototype IC was fabricated by MOSIS using AMI'S 1.5 mum, double poly, double level metal CMOS technology

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Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005.

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