{"title":"人血浆中阿米替林和去甲替林的灵敏测定方法。","authors":"T B Cooper, D Allen, G M Simpson","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A highly sensitive and reproducible GLC technique for the quantitation of amitriptyline and nortriptyline is described. The lower limit of detection is less than 1 ng/ml. 5 ng/ml samples (3 ml aliquots) can be accurately quantified (C of V less than 5%). Steady state data are reported together with data on amitriptyline and nortriptyline levels obtained in a volunteer who ingested a single oral dose (25 mg) of amitriptyline (Elavil).</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 2","pages":"105-16"},"PeriodicalIF":0.0000,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A sensitive method for the determination of amitriptyline and nortriptyline in human plasma.\",\"authors\":\"T B Cooper, D Allen, G M Simpson\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A highly sensitive and reproducible GLC technique for the quantitation of amitriptyline and nortriptyline is described. The lower limit of detection is less than 1 ng/ml. 5 ng/ml samples (3 ml aliquots) can be accurately quantified (C of V less than 5%). Steady state data are reported together with data on amitriptyline and nortriptyline levels obtained in a volunteer who ingested a single oral dose (25 mg) of amitriptyline (Elavil).</p>\",\"PeriodicalId\":76387,\"journal\":{\"name\":\"Psychopharmacology communications\",\"volume\":\"2 2\",\"pages\":\"105-16\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1976-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychopharmacology communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychopharmacology communications","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
描述了一种高灵敏度和可重复性的定量阿米替林和去甲替林的GLC技术。检测下限小于1 ng/ml。5 ng/ml样品(3 ml等分)可准确定量(C of V小于5%)。稳态数据与阿米替林和去甲替林水平的数据一起被报道，这些数据来自于一名志愿者，他服用了单次口服剂量(25mg)阿米替林(Elavil)。
A sensitive method for the determination of amitriptyline and nortriptyline in human plasma.
A highly sensitive and reproducible GLC technique for the quantitation of amitriptyline and nortriptyline is described. The lower limit of detection is less than 1 ng/ml. 5 ng/ml samples (3 ml aliquots) can be accurately quantified (C of V less than 5%). Steady state data are reported together with data on amitriptyline and nortriptyline levels obtained in a volunteer who ingested a single oral dose (25 mg) of amitriptyline (Elavil).
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