阿戈美拉汀与右美托咪定在清醒纤维插管中的潜在影响儿茶酚胺的作用

J. Attia, A. Hassanine
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引用次数: 0

摘要

背景清醒光纤插管是疑似气道困难的手术患者的推荐策略之一,特别是当预期同时通气困难时。患者和方法共90例男女患者,年龄在20 ~ 55岁之间,美国麻醉医师学会I期和II期为选择性腹部手术。患者被随机分为三组。A组:术前120分钟口服阿戈美拉汀,剂量为10mg,用水一小口给药。B组:阿戈美拉汀+右美托咪定。C组:右美托咪定每10 min负荷输注1 μg/kg,随后连续输注0.2 μg/kg/h。除血清去甲肾上腺素水平外,记录患者平均动脉压、心率、血氧饱和度、咳嗽评分、插管后评分、Richmond躁动镇静量表评分。结论阿戈美拉汀比右美托咪定在清醒光纤插管时具有更好的插管状态、镇静、低去饱和和血流动力学稳定性。检测阿戈美拉汀与右美托咪定的协同作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential effect of agomelatine versus dexmedetomidine during awake fiberoptic intubation; role of catacholamine
Background Awake fiber-optic intubation is one of the recommended strategies for surgical patients with suspected difficult airway, especially when simultaneous difficult ventilation is anticipated. Patients and methods In all, 90 patients of both sexes aged between 20 and 55 years, American Society of Anesthesiologist I and II stages were scheduled for elective abdominal surgeries. Patients were randomized into three equal groups. Group A: oral agomelatine at a dose of 10 mg administered with a sip of water 120 min before surgery. Group B: agomelatine+dexmedetomidine. Group C: dexmedetomidine infused at a dose of 1 μg/kg loading infusion per 10 min followed by a continuous infusion of 0.2 μg/kg/h. The following variables (mean arterial pressure, heart rate, oxygen saturation, cough score, postintubation score) and Richmond agitation sedation scale score were recorded in addition to the serum level of norepinephrine. Conclusion Agomelatine is more effective than dexmedetomidine in making better intubation state with sedation, less desaturation, and hemodynamic stability during awake fiber-optic intubation. Synergestic effect between agomelatine and dexmedetomidine was detected.
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