Association of claudin family protein in human cancer types: a network approach

Claudin family proteins are the most important components of the tight junctions (TJs). They are highly encompassing in human carcinoma such as lung, ovarian, breast, etc. This study sought to find protein-protein interaction network and the expression profile of claudins. The network result indicates the importance of tight junction protein1 and tight junction protein3 interactions with the class of various claudins. Moreover, screening of the three expression profiles through the assistance of gene set enrichment analysis and it is further validated by enrichment map. Our report had identified that lung adenocarcinoma, ovarian and hepatocellular carcinoma are responsible genes in claudins. An extent to expression profiles the enrichment map revealed the possible set of claudins in various cancers. Enrichment map helps to practically portray the vast quality genes, for example results of gene expression profiles. In conclusion, this computational study on gene network can emphasise the identification of new gene targets.