细胞免疫治疗领域生物医学文献的自动meta分析

D. Devyatkin, A. Molodchenkov, A. Lukin, Ya. S. Kim, A. Boyko, P. Karalkin, J. Chiang, G. D. Volkova, A. Lupatov
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引用次数: 1

摘要

基于细胞的免疫疗法是治疗慢性感染、自身免疫性疾病和恶性肿瘤的一种很有前途的方法。肿瘤细胞免疫治疗有多种策略;这些包括注射各种免疫效应细胞,在细胞培养中繁殖和“训练”。或者,细胞以免疫系统识别的形式在其表面呈递肿瘤抗原,可用于达到治疗效果。这一领域的研究成果在成千上万的文献中出现,它们的人工分析非常复杂。我们已经在生物医学科学的这个领域开发了一种自动文本分析的方法。在这里,我们展示了从PubMed上可获得的科学文章摘要中提取的数据的自动分析的第一个结果。这些结果表明肿瘤类型和最常用的基于细胞的免疫治疗方法之间存在关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Towards Automated Meta-analysis of Biomedical Texts in the Field of Cell-based Immunotherapy
Cell-based immunotherapy is a promising approach for the treatment of chronic infections, autoimmune disorders, and malignant tumors. There are many strategies of cell-based immunotherapy of cancer; these include injection of various immune effector cells, propagated and «trained» in a cell culture. Alternatively, cells presenting tumor antigens on their surface in a form recognized by the immune system can be used to achieve a therapeutic effect. The research results in this field are presented in thousands of texts, and their manual analysis is very complicated. We have developed an approach for automated text analysis in this area of biomedical science. Here we present the first results of the automated analysis of the data extracted from abstracts of scientific articles available in PubMed. These results demonstrate the associations between types of tumors and the most commonly used methods of their cell-based immunotherapy.
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