teduglutide在成人短肠综合征慢性肠衰竭患者中的应用:基于专家建议的治疗方案

Héctor Solar, A. Crivelli, Silvia de Barrio, Martin Buncuga, A. Manzur
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引用次数: 0

摘要

短肠综合征引起的慢性肠衰竭是一种严重而复杂的疾病,需要多学科的专业治疗。肠外营养是这些患者的基本支持;然而,从长期来看,与之相关的并发症可能会妨碍其连续性。在这种情况下,分离或联合肠道移植(肝-肠)是恢复肠道充分性的最后选择。自2012年引入全球以来,半合成GLP2肽(teduglutide)的使用改变了该疾病的病程和预后。阿根廷是使用这种肠激素经验最多的拉丁美洲国家,其结果与其他国际中心相当。这篇文章总结了专家建议在短肠综合征引起的慢性肠衰竭患者中使用teduglutide。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Teduglutida en pacientes adultos con falla intestinal crónica por síndrome de intestino corto: protocolo de manejo con base en recomendaciones de expertos
Chronic intestinal failure due to short bowel syndrome is a severe and complex disease that requires a specialized multidisciplinary treatment. Parenteral nutrition is the fundamental support in these patients; however, in the long term, complications associated with it may develop that contraindicate its continuity. In this context, an isolated or combined intestinal transplant (liver-intestine) is the last alternative to recover intestinal sufficiency. Since 2012 was introduced in the world, the use of semisynthetic GLP2 peptide, called teduglutide, changed the course and prognosis of this disease. Argentina is the Latin American country with the most experience in the use of this enterohormone, with results comparable to those of other international centers. This article summarizes the expert recommendations for the use of teduglutide in patients with chronic intestinal failure due to short bowel syndrome.
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