Winer结节性孤立性钙质沉着症的临床及皮肤镜特征

M. Asermouh, S. Maouni, C. A. Khabba, K. Znati, K. Senouci, M. Meziane
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摘要

目的:单发结节性皮肤钙质沉着症是一种罕见的、良性的局部特发性皮肤钙质沉着症。其皮肤镜特征可能对早期诊断有用,但据我们所知,从未在文献中描述过。病例报告:一名5岁儿童因右耳螺旋无痛性角化和疣状结节2年病史来到我们诊所。一种疣被怀疑和治疗没有任何改善。皮肤镜检查显示周围白色沉积物提示Winer钙质沉着症,促使手术切除,组织学检查证实了诊断。讨论:表皮下钙化结节在文献中很少被描述。目前还不知道它是否与磷钙代谢紊乱或其他全身性疾病有关。致病假说包括先前存在的皮肤结构的钙化,继发性钙质沉着的肥大细胞脱颗粒,或先前的创伤。皮肤钙沉积通常呈无定形和颗粒状,可被淋巴组织细胞浸润或巨细胞包围。尽管如此,皮肤镜检查可以通过显示这些白色的皮肤沉积物来帮助及时诊断。结论:Winer结节性钙质沉着症的诊断一直以组织学为基础,但本文首次描述的皮肤镜检查结果具有提示意义,可用于节省时间并排除其他鉴别诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical and Dermoscopic Features of Winer's Nodular Solitary Calcinosis
Aims: Solitary nodular calcinosis of Winer is a rare and benign form of localized idiopathic cutaneous calcinosis. Its dermoscopic features may be useful for early diagnosis, but have never been described in the literature to our knowledge. Case Report: A 5-year-old child presented to our clinic with a  2 years history of a painless keratotic  and warty nodule located in the helix of the right ear. A wart was suspected and treated without any improvement. Dermoscopy was performed and showed peripheral white deposits suggestive of Winer's calcinosis, motivating an excision whose histological examination confirmed the diagnosis. Discussion: The subepidermal calcified nodule has been rarely described in the literature. It is not known to be associated with a disorder of phosphocalcium metabolism or other systemic diseases. Pathogenic hypotheses include calcification of preexisting skin structures, mast cell degranulation with secondary calcinosis, or prior trauma. Surgical excision with histopathological confirmation is necessary to show the dermal calcium deposits, which are usually amorphous and granular and may be surrounded by a lymphohistiocytic infiltrate or giant cells. Nevertheless, dermatoscopic evaluation can aid in rendering a timely diagnosis by showing these whitish dermal deposits. Conclusion: The diagnosis of Winer's nodular calcinosis has always been based on histology, but the dermoscopy described here for the first time is so suggestive that it can be used to save time and exclude other differential diagnoses.
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