[原理氯化脂肪溶剂对家兔皮肤和眼粘膜的刺激性]。

European journal of toxicology and environmental hygiene. Journal europeen de toxicologie Pub Date : 1976-05-01

P Duprat, L Delsaut, D Gradiski

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引用次数: 0

摘要

为了比较主要的脂肪族氯化物溶剂和纯六氯丁二烯对兔皮肤和眼粘膜的刺激作用，在兔身上进行了一项研究。使用Draize的方法，即化妆品评估的官方技术和Kay和Calandra的解释，研究了一次应用或注入常见脂肪族氯化物溶剂的效果。肉眼观察后，对病变及其病程进行组织学检查。除三氯三氟-1,2,3-乙烷外，这些物质都是主要刺激物，但它们对兔皮肤和眼粘膜的影响不同。

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[Irritant power of the principle chlorinated aliphatic solvents on the skin and ocular mucosa of the rabbit].

A study was carried out in the rabbit in order to compare the cutaneous and ocular mucosa irritant powers of the principal aliphatic chloride solvents and of pure hexachlorobutadiene. Using Draize's method, that of the official technique for the assessment of cosmetic products and the interpretation of Kay and Calandra, a study was made of the effects of a single application or instillation of the common aliphatic chloride solvents. Macroscopic observations were followed by histological examination of the lesions and their course. With the exception of trichloro trifluoro-1,2,3-ethane, these substances are primary irritants but their effects on rabbit skin and ocular mucosa differ.

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European journal of toxicology and environmental hygiene. Journal europeen de toxicologie

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