精神分裂症患者血清氧化还原酶活性对细胞凋亡水平的影响

Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery) Pub Date : 2023-03-18 DOI:10.33920/med-01-2303-07

L. Smirnova, E. Epimakhova, D. Kazantseva, D. Kamaeva, A. Semke, S. Ivanova

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引用次数: 0

摘要

本文利用SH-SY5Y人神经母细胞瘤细胞系模型，研究了偏执型精神分裂症患者血清中过氧化氢酶和超氧化物歧化酶活性的IgG对凋亡细胞死亡参数的影响。对免疫球蛋白G的过氧化氢酶和超氧化物歧化酶活性进行了测定，证实这些活性属于抗体。体外实验首次证实，经24次培养后，精神分裂症缓解期患者的抗体酶可显著降低SH-SY5Y人神经母细胞瘤细胞系的凋亡水平。

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In vitro effect of serum IgGs with oxidoreductase activities of schizophrenic patients on apoptosis level

This paper presents the results of a study of the effect of IgG with catalase and superoxide dismutase activities, isolated from the blood serum of patients with paranoid schizophrenia, on the parameters of apoptotic cell death in an in vitro experiment, using a model of the SH-SY5Y human neuroblastoma cell line. The catalase and superoxide dismutase activities of immunoglobulins G were evaluated, and these activities were proved to belong to antibodies. It has been shown for the first time that abzymes from patients with schizophrenia in the therapeutic remission phase significantly reduce the level of apoptosis in the SH-SY5Y human neuroblastoma cell line after 24 incubations in an in vitro experiment.

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Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery)

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