五种精神药物对成年雌雄大鼠新生儿期行为反应的影响。

N M Fonseca, A B Sell, E A Carlini
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引用次数: 10

摘要

雄性和雌性大鼠在婴儿期接受生理盐水、苯巴比妥、氟哌啶醇、地西泮、氯丙嗪和安非他明的处理或注射。成年后,研究人员在露天竞技场和Lashley III迷宫中测量了这些动物的行为。生理盐水注射本身影响雄性的行为,但不能改变雌性的行为。药物引起雄性小鼠在野外活动增加和/或排便减少,而雌性小鼠则相反,即活动减少和/或排便增加。因此,早期药物治疗消除了通常观察到的大鼠行走和排便的性别差异。5种药物中有4种会使雄性和雌性大鼠的迷宫表现恶化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differential behavioral responses of male and female adult rats treated with five psychotropic drugs in the neonatal stage.

Male and female rats received during infancy either handling or injections of saline, phenobarbital, haloperidol, diazepam, chlorpromazine, and amphetamine. On reaching adulthood, the behavior of these animals was measured in an open-field arena and in a Lashley III maze. Saline injections per se affected the behavior of males but were unable to change that of females. The drugs provoked increased ambulation and/or decreased defecation of males in the open field, whereas with the females the opposite was observed, that is, a decreased ambulation and/or an increased defecation. Consequently, the early drug treatments abolished the sexual differences normally observed in ambulation and defecation of rats. Four of the 5 drugs tested deteriorated the maze performance of both male and female rats.

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