{"title":"自适应设计","authors":"G. Wassmer, F. Koenig, Martin Posch","doi":"10.1201/9781315119694-17","DOIUrl":null,"url":null,"abstract":"Adaptations Some of the methods used to adapt a clinical trial include: 1. Stopping one or more arms of a trial early for futility or efficacy and/or toxicity/safety; 2. Altering the allocation ratio, this could be based on information from responses or covariates, a. either by favouring better arms or b. dropping some arms completely; 3. Altering eligibility criteria; 4. Altering the size of the study; and 5. Altering primary endpoints.","PeriodicalId":362519,"journal":{"name":"Handbook of Statistical Methods for Randomized Controlled Trials","volume":"49 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Adaptive Designs\",\"authors\":\"G. Wassmer, F. Koenig, Martin Posch\",\"doi\":\"10.1201/9781315119694-17\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Adaptations Some of the methods used to adapt a clinical trial include: 1. Stopping one or more arms of a trial early for futility or efficacy and/or toxicity/safety; 2. Altering the allocation ratio, this could be based on information from responses or covariates, a. either by favouring better arms or b. dropping some arms completely; 3. Altering eligibility criteria; 4. Altering the size of the study; and 5. Altering primary endpoints.\",\"PeriodicalId\":362519,\"journal\":{\"name\":\"Handbook of Statistical Methods for Randomized Controlled Trials\",\"volume\":\"49 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Handbook of Statistical Methods for Randomized Controlled Trials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1201/9781315119694-17\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Handbook of Statistical Methods for Randomized Controlled Trials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1201/9781315119694-17","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Adaptations Some of the methods used to adapt a clinical trial include: 1. Stopping one or more arms of a trial early for futility or efficacy and/or toxicity/safety; 2. Altering the allocation ratio, this could be based on information from responses or covariates, a. either by favouring better arms or b. dropping some arms completely; 3. Altering eligibility criteria; 4. Altering the size of the study; and 5. Altering primary endpoints.
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