美沙酮与吗啡自我给药的剂量反应比较。

Psychopharmacologia Pub Date : 1976-05-28 DOI:10.1007/BF00735825

T E Werner, S G Smith, W M Davis

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引用次数: 15

摘要

大鼠自行给予0.9%生理盐水溶液，或0.01、0.03、0.1或0.3 mg/kg/次盐酸美沙酮或0.03、0.1或0.3 mg/kg/次硫酸吗啡。结果表明，注射次数与单位剂量成反函数关系，自我给药量(mg/kg)与单位剂量成正函数关系。数据还表明，自我给药的吗啡多于美沙酮。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A dose-response comparison between methadone and morphine self-administration.

Rats were allowed to self-administer a solution of 0.9% saline, or 0.01, 0.03, 0.1 or 0.3 mg/kg/infusion of methadone hydrochloride or 0.03, 0.1 or 0.3 mg/kg/infusion of morphine sulfate. The results showed that number of infusions taken was an inverse function of unit dose, while amount of drug self-administered (mg/kg) was a direct function of unit dose. The data also indicated that more morphine than methadone was self-administered.

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Psychopharmacologia

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