从功能微电极阵列逐层洗脱米诺环素薄膜的电学分析

Matthew D. McDermott, Kaitlynn P. Olczak, K. Otto
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引用次数: 1

摘要

尽管皮质内植入微电极的潜力已被证明,但由于其在临床相关时间点(数年至数十年)无法发挥作用,成功的临床转化一直受到阻碍。植入微电极阵列(MEA)的失败与异物反应高度相关,异物反应逐渐将MEA封装在胶质鞘中,将其与周围的微环境隔离开来。为了减轻这种反应,已经实施了药物递送以从设备表面释放治疗药物。这使得在紧急时间点取得的成功有限;然而,维持长期治疗剂量的挑战导致无法减轻慢性炎症。最近的一份出版物展示了使用由葡聚糖硫酸盐、盐酸米诺环素(MH)和A型明胶组成的多层膜,通过逐层技术组装,能够持续释放MH数周;然而,它们对功能的影响尚未被分析。我们发现,在涂覆20层NeuroNexus器件后,在100Hz, 1kHz和10kHz处的阻抗显着增加,尽管在PBS中孵育24小时后显着降低。PBS孵育后,载电荷能力也显著提高。可以得出结论,这些涂层在涂层后确实会立即影响MEA,但随着涂层的降解,影响会随着时间的推移而减弱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Electrical analysis of minocycline eluting layer-by-layer thin-films from functional micro-electrode arrays
Although the potential for intracortical implanted microelectrodes has been demonstrated, successful clinical translation has been hindered by their inability to function over clinically relevant time-points (years to decades). Failure of implanted microelectrode arrays (MEA's) has been highly correlated with the foreign body response which progressively encapsulates the MEA's in a glial sheath, isolating them from the surrounding microenvironment. To mitigate this response, drug delivery has been implemented to release therapeutics from the device surface. This has allowed limited success at acute time points; however, challenges in maintaining longterm therapeutic dosages has resulted in an inability to mitigate chronic inflammation. A recent publication has demonstrated the use of multi-layer film composed of dextran-sulfate, minocycline hydrochloride (MH), and gelatin type A, assembled via layer-by-layer technology, capable of providing sustained release of MH for several weeks; however, their impact on functionality has not yet been analyzed. We found that after being coated with 20 layers NeuroNexus devices exhibited significantly increased impedance at 100Hz, 1kHz, and 10kHz, though this was significantly reduced after 24-hours of incubation in PBS. Charge carrying capacity also significantly increased after incubation in PBS. It can be concluded that these coatings do influence MEA's immediately after coating, but is less impactful over time as the coating degrades.
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