Rebecca Cabral-Dias, Stefanie Lucarelli, Karolina Zak, Sadia Rahmani, Gurjeet Judge, John Abousawan, Laura F DiGiovanni, Dafne Vural, K. Anderson, Michael G. Sugiyama, G. Genç, W. Hong, R. Botelho, G. Fairn, P. Kim, C. Antonescu
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Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling
Ligand binding to EGF receptor (EGFR) triggers signaling and concomitant receptor recruitment to clathrin-coated pits. This study reveals that the signaling adaptor TOM1L1 recruits Fyn to a specialized subset of clathrin-coated pits and is required for SHIP2 recruitment and regulation of Akt signaling by EGFR.
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