植物WEE1激酶与14-3-3蛋白GF14ω相互作用，但WEE1在S485位点的突变改变了它们的空间相互作用

The Open Plant Science Journal Pub Date : 2009-06-02 DOI:10.2174/1874294700903010040

A. L. Gronlund, J. Dickinson, P. Kille, J. Harwood, R. Herbert, D. Francis, H. Rogers

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引用次数: 12

摘要

在动物中，14-3-3蛋白结合两个细胞周期蛋白WEE1和CDC25，稳定其磷酸化状态。本文首次报道了WEE1与14-3-3蛋白在植物体内和体外的相互作用。拟南芥14-3-3家族分为Epsilon或Non-Epsilon组。在酵母2杂交筛选中，拟南芥WEE1与Non-Epsilon组相互作用。随后，我们专注于Non-Epsilon GF14

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Plant WEE1 Kinase Interacts with a 14-3-3 Protein, GF14ω but a Mutation of WEE1 at S485 Alters Their Spatial Interaction

In animals, 14-3-3 proteins bind two cell cycle proteins WEE1 and CDC25 stabilising their phosphorylated state. We report here for the first time interactions between WEE1 and 14-3-3 proteins both in vitro and in vivo in plants. The Arabidopsis 14-3-3 family partitions into either an Epsilon or Non-Epsilon group. In a yeast 2-hybrid screen Arabidopsis WEE1 interacted with the Non-Epsilon group. Subsequently, we focussed on Non-Epsilon GF14

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The Open Plant Science Journal

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