一个警世故事:如果隐身适应病毒将Covid-19刺突蛋白编码mRNA纳入其基因组中会怎么样?

W. J. Martin
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引用次数: 0

摘要

隐性适应是一种普遍的逃避机制,所有病毒都是通过删除或突变编码相对较少的病毒成分的基因,这些基因通常被细胞免疫系统靶向。某些隐身适应病毒的另一个特征是合并了细胞和细菌来源的额外基因序列,这些“叛变”的基因序列随后可作为传染性隐身适应病毒的组成部分在人与人之间传播。该病毒是一种非洲绿猴类人猿巨细胞病毒(SCMV)的衍生物,它培养了慢性疲劳(CFS) a病毒(隐身病毒-2)精神病隐身病毒-1的克隆,并将248个克隆的全部或部分DNA序列提交GenBank。在这些克隆中,有200个序列对应于SCMV基因组的区域。这些序列不均匀地分布在起源SCMV的基因组中,具有明显的主要缺失和遗传不稳定性。从人类基因组的非编码区获得了14个克隆基因序列。这些合并的细胞序列也发生了遗传变化,表明在遗传上隐身适应病毒基因组的34个序列来自隐身病毒-1蛋白编码序列。这些序列与隐身适应细菌和细胞内细菌共同感染,细菌衍生序列具有特定的代谢功能和/或替代一些普通的衣壳。隐身病毒-1的整体基因组在遗传上是碎片化的,细胞和细菌衍生序列可能通过与隐身细胞序列片段的交联纳入病毒基因组
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Cautionary Tale: What if Stealth Adapted Viruses Incorporate the Covid-19 Spike Protein Coding mRNA into Their Genome?
Stealth adaptation a generic evasion mechanism, with all viruses It the deletion or mutation of the genes coding for the relatively few virus components typically targeted by the cellular immune system. A further characteristic of certain stealth adapted viruses is the incorporation of additional genetic sequences of cellular and bacterial origins These “renegade” genetic sequences can be subsequently transmitted between humans as components of infectious stealth adapted viruses. The best characterized stealth adapted virus, referred in GenBank as stealth virus a derivative of an African green monkey simian cytomegalovirus (SCMV) It cultured a the chronic fatigue (CFS) A virus (stealth virus-2) psychosis Stealth virus-1 cloned and complete or partial DNA sequences of 248 clones submitted GenBank. Of these clones, 200 of the sequences correspond to regions of the SCMV genome. The sequences are unevenly distributed over the genome of the originating SCMV, with clear major deletions and genetic instability. Fourteen clones genetic sequences that were derived from non-coding regions of the human genome. These incorporated cellular sequences also undergone genetic changes indicative of the genetically stealth adapted virus genome Thirty-four sequences from stealth virus-1 protein-coding sequences. These sequences coinfection of with both stealth adapted and intracellular bacteria, with the bacteria-derived sequences specific metabolic functions and/or substituting for some of the ordinary capsids The overall genome of stealth virus-1 is genetically fragmented the likelihood of the cellular and bacteria-derived sequences incorporated into the virus genome by the cross-linking of fragments from the Cellular sequences incorporated into the stealth
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